Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology-Surgical

Background aims: HCC is an aggressive malignancy and has multiple treatment options, usually a multimodality therapy is used. The choice treatment depends on many factors including staging of tumor, patient characteristics and liver functions. This study aimed to provide a descriptive analysis of patients diagnosed with HCC in NCI and to evaluate the outcome of treatment by surgical resection and interventional radiology. Methods: The study included 84 patients of both sexes diagnosed with HCC in NCI and were retrospectively reviewed for patients{u2019} characteristics, mode of presentation, investigations done, staging and treatment received. Treatment outcome was compared between the two groups regarding the local control and survival. Reuslts: Mean age was found to be 56.1 and 58.3 in SR group and IR group respectively. HCV was positive in 88% of the patients. 41 patients (48.8%) were child class A, 35 patients (41.7%) were child class B and 8 patients (9.5%) were class C. Median follow up time was 15.21 months. Recurrence rate was (42.2%) in the SR group compared to (58.9%) patients in the IR group. The 1-, 3- and 5-year overall survival for the SR group was 79%, 54% and 28% respectively while it was 55%, 11% and 5% for the IR group respectively. Conclusion: Surgical treatment remains the only curative therapy for HCC, with lower recurrence rates and longer survival. However, other modalities be used in conjunction with surgery or as a bridge to liver transplantation. Further studies are required in NCI to develop the optimum therapy or combination of therapies for HCC

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