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Design and synthesis of flexible triphenylethylenes and their evaluation as anticancer Agents / Rahma Mostafa Mahmoud Mansour Elbagoury ; Supervised Ashraf H. Abadi , Nermin S. Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rahma Mostafa Mahmoud Mansour Elbagoury , 2017Description: 91 Leaves : charts , facsimiles ; 30cmOther title:
  • تصميم وتشييد ثلاثي الفينيل إثلين وتقييمها كعناصر مضادة للسرطان [Added title page title]
Subject(s): Online resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry Summary: Tamoxifen is considered the gold standard for first-line treatment of all stages of breast cancer. It can be considered a classic "pro-drug" requiring metabolic activation to elicit pharmaceutical activity . CYP2D6 is the rate {u2013} limiting enzyme catalyzing the conversion of tamoxifen into metabolites with significantly greater affinity for the ER and greater ability to inhibit cell proliferation
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry

Tamoxifen is considered the gold standard for first-line treatment of all stages of breast cancer. It can be considered a classic "pro-drug" requiring metabolic activation to elicit pharmaceutical activity . CYP2D6 is the rate {u2013} limiting enzyme catalyzing the conversion of tamoxifen into metabolites with significantly greater affinity for the ER and greater ability to inhibit cell proliferation

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