Design and synthesis of flexible triphenylethylenes and their evaluation as anticancer Agents / Rahma Mostafa Mahmoud Mansour Elbagoury ; Supervised Ashraf H. Abadi , Nermin S. Ahmed
Material type:
- تصميم وتشييد ثلاثي الفينيل إثلين وتقييمها كعناصر مضادة للسرطان [Added title page title]
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2017.Ra.D (Browse shelf(Opens below)) | Not for loan | 01010110075352000 |
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry
Tamoxifen is considered the gold standard for first-line treatment of all stages of breast cancer. It can be considered a classic "pro-drug" requiring metabolic activation to elicit pharmaceutical activity . CYP2D6 is the rate {u2013} limiting enzyme catalyzing the conversion of tamoxifen into metabolites with significantly greater affinity for the ER and greater ability to inhibit cell proliferation
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