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Study of vitamin D level and vitamin D receptor polymorphism in hypothyroid Egyptian patients / Mai Mohamed Fawzy Mansour ; Supervised Hoda Abdelsattar Elrawi , Laila Ahmed Rashed , Nashwa Said Mohamed Ghanem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Mohamed Fawzy Mansour , 2017Description: 145 P. : facsimiles ; 25cmOther title:
  • دراسة مستوى فيتامين د و الاشكال المتعددة لمستقبلات فيتامين د فى المرضى المصريين المصابين بنقص نشاط الغدة الدرقية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Background: Vitamin D level is thought to be involved in many diseases, and is thought to be found in autoimmune thyroid diseases. Vitamin D receptor polymorphism is now emerging as a cause of vitamin D deficiency in many diseases in all populations. Aim: The current case-control study aimed at assessment of vitamin D level and vitamin D receptor polymorphism in hypothyroid patients and its effect on hypothyroidism and to find a causal relation between vitamin D and hypothyroidism. Subjects and methods: The current study included 35 hypothyroid patients and 35 matched unrelated healthy controls. Genotyping was performed by using real time-PCR (TaqMan probes). Results: The study showed that vitamin D level is lower in hypothyroid patients than in control subjects. It is also inversely related to TSH, HOMA-IR, level of anti-TG and anti-TPO. VDR polymorphism has no relation to TSH and vitamin D levels. Conclusion: The study confirmed association of vitamin D deficiency with hypothyroidism, autoimmunity, increased volume, nodularity and vascularity of thyroid gland in hypothyroid patients as well as increased HOMA-IR. The study proved no association between VDR polymorphisms with both vitamin D levels and TSH levels
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2017.Ma.S (Browse shelf(Opens below)) Not for loan 01010110075470000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2017.Ma.S (Browse shelf(Opens below)) 75470.CD Not for loan 01020110075470000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Vitamin D level is thought to be involved in many diseases, and is thought to be found in autoimmune thyroid diseases. Vitamin D receptor polymorphism is now emerging as a cause of vitamin D deficiency in many diseases in all populations. Aim: The current case-control study aimed at assessment of vitamin D level and vitamin D receptor polymorphism in hypothyroid patients and its effect on hypothyroidism and to find a causal relation between vitamin D and hypothyroidism. Subjects and methods: The current study included 35 hypothyroid patients and 35 matched unrelated healthy controls. Genotyping was performed by using real time-PCR (TaqMan probes). Results: The study showed that vitamin D level is lower in hypothyroid patients than in control subjects. It is also inversely related to TSH, HOMA-IR, level of anti-TG and anti-TPO. VDR polymorphism has no relation to TSH and vitamin D levels. Conclusion: The study confirmed association of vitamin D deficiency with hypothyroidism, autoimmunity, increased volume, nodularity and vascularity of thyroid gland in hypothyroid patients as well as increased HOMA-IR. The study proved no association between VDR polymorphisms with both vitamin D levels and TSH levels

Issued also as CD

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