Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology

Introduction: This study was an experimental study to investigate the role of Mg sulfate and esomeprazole on the treatment of the deleterious effects observed in experimentally induced preeclampsia in pregnant rats by L-NAME. Materials and methods: 40 adult pregnant females Sprague Dawley albino rats divided in to four groups. Group 1 controlled pregnant rats, Group 2 preeclampsia group induction with L-NAME (80 mg/kg/day) from gestational day 10 to end of pregnancy, Group 3 preeclampsia group treated with Mg sulfate (500mg/kg/day, orally) from gestational day 14 to the end of pregnancy and Group 4 preeclampsia group treated with Esomeprazole (3.5mg/kg/day, orally) starting from gestational day 14 to the end of pregnancy. Systolic blood pressure was recorded throughout pregnancy, EEG was recorded at gestational day 18. Blood samples from rat tail vein taken for estimation of serum Mg and soluble Endogolin levels at the start of pregnancy, gestational day 14 and at the end of pregnancy. Urine samples at the end of pregnancy taken for estimation of urine protien creatinine ratio. After delivery, maternal behaviour, reproductive outcome including total number of pups and fetal weights were assessed. Results: In comparison with the L-NAME group, Mg sulfate and esomeprazole treatment reduced the values of systolic blood pressure, proteinuria, EEG amplitude, prevented preterm labor and improved maternal behaviour after delivery and fetal outcomes

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