Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: NHLs are an etiologically, clinically, and histologically heterogeneous group of lymphoproliferative disorders. Obesity has been found to be a risk factor through dysregulation of a large spectrum of inflammatory and adiposity cytokines. Aims: We aimed to Study the association between obesity as measured by body mass index (BMI), and risk of non-Hodgkin lymphoma (NHL) development by evaluating the role of inflammatory cytokines, (IL-6, IL-10, IFN-gamma and CRP) and adipokines (leptin and adiponectin). Methods: We measured the circulatory levels of IL-6, IL-10, IFN-Þ, CRP, LEP and APN by special ELISA kits in sera of 45 NHL Egyptian cases in comparison with 43 healthy controls and correlate results with their BMI. Results: All the inflammatory markers (IL-6, IL-10, IFN-Þ. & CRP) together with adiponectin were statistically higher in B-NHL cases than control. When studied inflammatory & adiposity markers in two groups of patients subgrouped by BMI (< & {u2265} 25 kgm²), we found positive significant difference with leptin (p-value 0.001) with higher levels in patients with BMI ({u2265} 25 kg/m²). Summary / Conclusion: IL-6, IL-10, CRP, IFN-Þ and adiponectin are implicated in lymphomagenesis. Inflammatory markers as well as adipokines could be used to anticipate NHL development. Also, we support the hypothesis that obesity has a major role in the development of NHL, as we found association between leptin and NHL risk with higher levels in patients with BMI ({u2265} 25 kg/m²)

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