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Design, synthesis and biological evaluation of nitrogenous heterocyclic derivatives / Abdallah Mohamed Abdalhaleem Alfayomy ; Supervised Fatma Abdelfattah Ragab , Sahar Mahmoud Abouseri , Salah Abdelmuttalib Abdelaziz

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Abdallah Mohamed Abdalhaleem Alfayomy , 2018Description: 160 P. : charts ; 25cmOther title:
  • تصم{u٠٦أأ}م وتش{u٠٦أأ}{u٠٦أأ}د واختبار الفاعل{u٠٦أأ}ة الب{u٠٦أأ}ولوج{u٠٦أأ}ة لبعض المركبات الغ{u٠٦أأ}ر متجانسة الحلقة المحتو{u٠٦أأ}ة علي الن{u٠٦أأ}تروج{u٠٦أأ}ن [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Encouraged by the anticancer activity exhibited by dihydropyrimidines (DHPMs), novel substituted dihydropyrimidine hybrids containing 1,3,4-oxadiazole or coumarin moieties were designed, synthesized and investigated for their cytotoxic activity. The newly synthesized compounds were screened for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI (USA) protocol. The IC50 of compounds 9i, 9k, 9l, 9m, 9n, 9p and 9r have been evaluated against the most sensitive cancer cell lines, leukemia HL-60(TB) and MOLT-4 cell lines. The most active compounds were 9m against HL-60(TB) (IC50= 56 nM) and 9n against MOLT-4 (IC50= 80 nM), more potent than monastrol (IC50= 147 and 215 nM, respectively). Cell cycle analysis of HL-60(TB) cells treated with 9m and MOLT-4 cells treated with 9n showed cell cycle arrest at G2/M phase and pro-apoptotic activity as indicated by annexin V-FITC staining
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2018.Ab.D (Browse shelf(Opens below)) Not for loan 01010110075659000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2018.Ab.D (Browse shelf(Opens below)) 75659.CD Not for loan 01020110075659000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Encouraged by the anticancer activity exhibited by dihydropyrimidines (DHPMs), novel substituted dihydropyrimidine hybrids containing 1,3,4-oxadiazole or coumarin moieties were designed, synthesized and investigated for their cytotoxic activity. The newly synthesized compounds were screened for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI (USA) protocol. The IC50 of compounds 9i, 9k, 9l, 9m, 9n, 9p and 9r have been evaluated against the most sensitive cancer cell lines, leukemia HL-60(TB) and MOLT-4 cell lines. The most active compounds were 9m against HL-60(TB) (IC50= 56 nM) and 9n against MOLT-4 (IC50= 80 nM), more potent than monastrol (IC50= 147 and 215 nM, respectively). Cell cycle analysis of HL-60(TB) cells treated with 9m and MOLT-4 cells treated with 9n showed cell cycle arrest at G2/M phase and pro-apoptotic activity as indicated by annexin V-FITC staining

Issued also as CD

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