Potential therapeutic effect of commercial products of zingiber officinale (Ginger) and allium sativum (Garlic) on giardiasis in experimentally infected animals / Fatma Mamdouh Azouz Eissa ; Supervised Jumana Abdelaziz Ahmed , Iman Raafat Mohamed Riad , Shaimaa Helmy Elsaid

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Parasitology

Giardia lamblia is considered one of the most common protozoal parasites in humans. It is the causative agent of giardiasis, a major cause of diarrheal illness. This study was conducted to detect the potential effect of commercial products of Zingiber officinale (Ginger) and Allium sativum (Tomex plus) with metronidazole (Flagyl) as a control in experimental Giardiasis in hamsters. Both medicinal plants were tested alone and in combination with metronidazole. Parasitological assessment including cysts count, cysts viability and trophozoites count as well as histopathological assessment of the drug effect were done. Results revealed that the percentage of reduction in cysts number 2 weeks post treatment in the Zingiber officinale, Allium sativum, Zingiber officinale & metronidazole and Allium sativum & metronidazole treated groups were of 88.9%, 84.5%, 86.1% & 82% respectively compared to infected non-treated group and Metronidazole treated group showed percentage of reduction 79.7% with no statistical significant difference. while, the percentage of reduction in cyst viability was (76.9%, 73.4%, 70.7% & 64.9%) respectively compared to (61.9%) in the Metronidazole treated group with statistical significant difference in Zingiber Officinale treated group. In addition, the percentage of reduction in the trophozoites number 2 weeks post treatment was (60.2%, 64.1%, 47.3% & 59.4%) respectively compared to (38.6%) in metronidazole treated group with high statistical significant difference

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