Impact of molecular profiling of breast cancer regarding the rate of local recurrence in young versus old female patients / Hesham Mostafa Abdelhamid Mohamed Soliman ; Supervised Hassan Mahmoud Abdalla , Mohamed Akram Nouh , Eman Mohamed Touny

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology-Surgical

Background: Local recurrence in breast cancer patients have been traditionally linked to clinicopathological factors such as tumor size, age and nodal status. However, recent studies investigating the impact of subtyping breast cancer have proven it to be a powerful predictor of survival and distant recurrence, and has the potential towards decreasing the incidence of local recurrence through influencing the strategies for local control of breast cancer. Objective: To assess the rate of local recurrence of different breast cancer subtypes in old versus young patients. Methods: This is a retrospective study from the records of NCI from 1st of January 2012 till 31st of December 2014. The study will compare between the rates of local recurrence of different breast cancer subtypes in old versus young patients, excluding those with metastatic disease. Results: A total of 92 patients were included in the study. 30 patients were allocated to the young age group, while 62 patients were in the old age group. With regarding the incidence of local recurrence in both groups, the highest subtype was the triple negative; 11 and 32 patients in the young and old age group respectively. Next was the Her-2/neu enriched subtype; 9 and 28 patients in the young and old age group respectively, followed by the luminal a subtype; 6 and 22 patients in the young and old age group respectively. And lastly, the luminal B subtype; 4 and 10 patients in the young and old age group respectively. Conclusion: The incidence of local recurrence after surgery for breast cancer is more common in luminal negative subtypes and highest with the triple negative subtype

Issued also as CD