Study the efficiency of graphene oxide nanocomposite as a novel photothermal candidate : In vitro study / Marwa Ali Ramadan Hasan ; Supervised Tareq Youssef Abdeloahed , Samah Aly Loutfy , Taher Ahmed Salaheldin

Thesis (Ph.D.) - Cairo University - National Institute for Laser Enhanced Sciences - Department of Laser Applications In Environmental Metrology Photochemistry and Photobiology

Among various nanomaterials, graphene, a novel carbon-based nanomaterial, has attracted a great deal of attention due to its remarkable physical, chemical, and biological characteristics. Graphene has sparked enormous interest in many research groups around the world, and has resulted in unexpected increase in publications on the subject and recently in Geim and Novoselov{u2019}s Nobel Prize in Physics (2010). Besides pure graphene or graphene oxide (GO), numerous graphene based composite nanomaterials fabricated by integrating graphene or GO with various types of nanoparticles have also been widely explored, showing a great promise in energy research [¹⁻³], catalysis [₄,₅], electrochemical analysis [⁶], and other areas. Among these composite materials, graphene magnetite nanocomposite (G/Fe₃O₄) which have been synthesized by a number of groups and used for a variety of purposes. [₇,₈] In the present study, GO, rGO, Fe₃O₄ and (G/Fe₃O₄) nanocomposite, were synthesized with excellent stability in water. The resulting composite combined the both features of (Fe₃O₄) and graphene, and thus exhibited extraordinary advantages of the superparamagnetic properties, and strong optical absorption of (G/Fe₃O₄), photothermal therapy (PTT) in vitro to selectively destroy cancer cells. The (G/Fe₃O₄) composite prepared in this work may be a promising multifunctional nanoplatform for cancer therapy

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