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Potential therapeutic role of mesenchymal stem cell in delayed wound healing of diabetic rats / Mostafa Abdalla Mohamed Gad ; Supervised Adel M. Aboelfetouh Elbehairy , Mohamad A. A. Warda , Abdelbary Mohamed Prince

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mostafa Abdalla Mohamed Gad , 2018Description: 141 P. : charts , facsimiles ; 25cmOther title:
  • الدور العلاجى المحتمل للخلايا الجذعية فى إلتئام الجروح المتأخر للجرذان المصابه بالسكرى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition Summary: The aim of the present work was to investigate the effect of BM-MSCs on wound closure in STZ-induced diabetic rats. Diabetic wound models were carried out by making a standard wound on dorsum of forty rats, which were divided into four groups with ten rats in each: Wound from diabetic and non-diabetic control rats were treated with PBS, while diabetic and non-diabetic treated rats were treated with BM-MSCs for 12 days. The closure rate and the ratios relative to the beta actin gene of both treated groups (diabetic and non-diabetic) were significantly increased at 7 and 12 days after wounding as compared to their corresponding controls (P < 0.05). Histologic analysis revealed complete re-epithelialization in treated groups. Taken together, BM-MSCs mediated correction of the diabetic wound healing impairment is due to, partly, increased VEGF expression in the skin of STZ-induced diabetic rats
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.M.Sc.2018.Mo.P (Browse shelf(Opens below)) Not for loan 01010110075944000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.M.Sc.2018.Mo.P (Browse shelf(Opens below)) 75944.CD Not for loan 01020110075944000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition

The aim of the present work was to investigate the effect of BM-MSCs on wound closure in STZ-induced diabetic rats. Diabetic wound models were carried out by making a standard wound on dorsum of forty rats, which were divided into four groups with ten rats in each: Wound from diabetic and non-diabetic control rats were treated with PBS, while diabetic and non-diabetic treated rats were treated with BM-MSCs for 12 days. The closure rate and the ratios relative to the beta actin gene of both treated groups (diabetic and non-diabetic) were significantly increased at 7 and 12 days after wounding as compared to their corresponding controls (P < 0.05). Histologic analysis revealed complete re-epithelialization in treated groups. Taken together, BM-MSCs mediated correction of the diabetic wound healing impairment is due to, partly, increased VEGF expression in the skin of STZ-induced diabetic rats

Issued also as CD

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