header
Image from OpenLibrary

Antiviral evaluation of secondary metabolites derived from actinomycetes conjugated to silver nanoparticles / Heba Ali Ali Abdelgaied ; Supervised Abdelgawad Hashem , Marwa Elrakaiby , Aly Fahmy Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Heba Ali Ali Abdelgaied , 2018Description: 148 P. : charts , facsimiles ; 25cmOther title:
  • تقييم النشاط المثبط للفيروسات لنواتج الأبيض الثنائية للأكتينوميسيتس المحملة على جزيئات الفضة النانونية [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology Summary: Virus infections pose significant global health challenges, due to the emergence of resistant viruses. Therefore, it is imperative that safe and conventional antiviral drugs be developed. In the present study, Actinomycetes isolated form Egyptian soil samples were used to investigate the possibility of acquiring antiviral activity from their metabolites by testing against three selected virus models. Results revealed that the sixth fraction purified from isolate (HA1) metabolites induced significant reduction of virus infectivity titer recording 62%, 46.5% and 44.1% log reduction in virus infectivity for HAV, HSV-2 and VSV respectively and the isolate was identified as Streptomyces avermitilis as blasted on the NCBI database. Further evaluation of the antiviral activity of the metabolite against the three virus models was attempted by conjugation to silver nanoparticles
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2018.He.A (Browse shelf(Opens below)) Not for loan 01010110075971000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2018.He.A (Browse shelf(Opens below)) 75971.CD Not for loan 01020110075971000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

Virus infections pose significant global health challenges, due to the emergence of resistant viruses. Therefore, it is imperative that safe and conventional antiviral drugs be developed. In the present study, Actinomycetes isolated form Egyptian soil samples were used to investigate the possibility of acquiring antiviral activity from their metabolites by testing against three selected virus models. Results revealed that the sixth fraction purified from isolate (HA1) metabolites induced significant reduction of virus infectivity titer recording 62%, 46.5% and 44.1% log reduction in virus infectivity for HAV, HSV-2 and VSV respectively and the isolate was identified as Streptomyces avermitilis as blasted on the NCBI database. Further evaluation of the antiviral activity of the metabolite against the three virus models was attempted by conjugation to silver nanoparticles

Issued also as CD

There are no comments on this title.

to post a comment.