Comparative study of the change in liver enzymes after general or spinal anesthetic techniques in patients with preoperatively elevated liver enzymes / Shady Aboelela Ismaiel ; Supervised Hala Mostafa Gomaa , Ahmed Abdalla Mohamed , Norhan Abdelaleem Ali

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Shady Aboelela Ismaiel

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TextLanguage: English Publication details: Cairo : Shady Aboelela Ismaiel , 2018Description: 75 P. : charts , facsimiles ; 25cmOther title:

دراسة مقارنة للتغيرات في انزيمات الكبد بعد اجراء التخدير العام أو التخدير النصفي في المرضى الذين يعانون من انزيمات كبد مرتفعة قبل الجراحة [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: Purpose: The Aim of this study was to compare the change in liver enzymes in patients with elevated liver enzymes preoperatively after general or spinal anesthetic techniques. Methods: A total of 60 patients with stationary raised liver enzymes were enrolled in this randomized prospective comparative study and were allocated randomly into two groups scheduled for lower limb or extraperitoneal lower abdominal surgery: Group A (n=30) where general anesthesia was used, Group B (n=30) where spinal anesthesia was used. The liver function tests (AST, ALT, Total and direct Bilirubin) were measured preoperatively and after 24 and 48 hours postoperatively. Intraoperative monitoring of vital signs, vasopressor use and fluid replacement were recorded. Results: There were no significant differences between the two groups regarding the age, gender, medical history, duration or type of surgery performed and intraoperative adverse events. As for intraoperative vital signs, no difference between the two groups regarding the heart rate. Group (B) experienced significantly lower blood pressure during the surgery compared to group (A) (P<0.05). All the liver enzymes were elevated significantly in both study groups postoperatively (Repeated measures ANOVA, P<0.05). However, No significant difference was found between the two groups at each measurement point (Independent samples t test, P>0.05). Conclusions: General anesthesia and Spinal anesthesia both cause mild elevation of Liver function tests in asymptomatic patients with elevated liver enzymes preoperatively. Careful monitoring and choosing appropriate anesthetic regimen and drugs are essential to minimize the effect of anesthetics on liver function tests and the liver condition in such patients

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.01.M.Sc.2018.Sh.C (Browse shelf(Opens below))		Not for loan		01010110076058000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.01.M.Sc.2018.Sh.C (Browse shelf(Opens below))	76058.CD	Not for loan		01020110076058000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Purpose: The Aim of this study was to compare the change in liver enzymes in patients with elevated liver enzymes preoperatively after general or spinal anesthetic techniques. Methods: A total of 60 patients with stationary raised liver enzymes were enrolled in this randomized prospective comparative study and were allocated randomly into two groups scheduled for lower limb or extraperitoneal lower abdominal surgery: Group A (n=30) where general anesthesia was used, Group B (n=30) where spinal anesthesia was used. The liver function tests (AST, ALT, Total and direct Bilirubin) were measured preoperatively and after 24 and 48 hours postoperatively. Intraoperative monitoring of vital signs, vasopressor use and fluid replacement were recorded. Results: There were no significant differences between the two groups regarding the age, gender, medical history, duration or type of surgery performed and intraoperative adverse events. As for intraoperative vital signs, no difference between the two groups regarding the heart rate. Group (B) experienced significantly lower blood pressure during the surgery compared to group (A) (P<0.05). All the liver enzymes were elevated significantly in both study groups postoperatively (Repeated measures ANOVA, P<0.05). However, No significant difference was found between the two groups at each measurement point (Independent samples t test, P>0.05). Conclusions: General anesthesia and Spinal anesthesia both cause mild elevation of Liver function tests in asymptomatic patients with elevated liver enzymes preoperatively. Careful monitoring and choosing appropriate anesthetic regimen and drugs are essential to minimize the effect of anesthetics on liver function tests and the liver condition in such patients

Issued also as CD

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