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A Study on the possible lipid lowering action of some phytochemical agents against experimentally induced hyperlipidemia in rats / Hayat Ahmed Abdelaal ; Supervised Helmy Moawad S. Ahmed , Hala M. Fawzy , Lamiaa A. Attia

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hayat Ahmed Abdelaal , 2018Description: 169 P. : charts , facsimiles ; 25cmOther title:
  • دراسة التأثير المحتمل الخافض للدهون لبعض الكيماويات النباتية ضد ارتفاع الدهون المحدث تجريبيا فى الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: The present investigation was designed to examine the possible hypolipidemic effect of ellagic acid, caffeic acid or carvacrol alone or in combination with simvastatin on polxamer 407 (P407) induced hyperlipidemia. Rats were injected with P407, (500 mg/ kg; i.p.), every 3 days, for 30 days. Treatment was carried out by adminstration of simvastatin (SIM) (20 mg/kg/day; p.o.), ellagic acid (EA), caffeic acid (CA) or carvacrol (CARV) (50 mg/kg/day; p.o.) or combination of SIM with each of the tested drugs. Treatment with SIM, EA, CA or CARV significantly decreased total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), atherogenic index, leptin and increased high density lipoprotein (HDL-c) and adiponectin. Moreover, combination of EA, CA or CARV with SIM potentiated the hypolipidemic effect of SIM and significantly ameliorated simvastatin-induced liver and muscle injury by reducing the level of alanine amiotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) and myoglobin and restoring the normal histological picture of both liver and muscle as well as decreased caspase 3 immunoreactivity
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2018.Ha.S (Browse shelf(Opens below)) Not for loan 01010110076111000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2018.Ha.S (Browse shelf(Opens below)) 76111.CD Not for loan 01020110076111000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The present investigation was designed to examine the possible hypolipidemic effect of ellagic acid, caffeic acid or carvacrol alone or in combination with simvastatin on polxamer 407 (P407) induced hyperlipidemia. Rats were injected with P407, (500 mg/ kg; i.p.), every 3 days, for 30 days. Treatment was carried out by adminstration of simvastatin (SIM) (20 mg/kg/day; p.o.), ellagic acid (EA), caffeic acid (CA) or carvacrol (CARV) (50 mg/kg/day; p.o.) or combination of SIM with each of the tested drugs. Treatment with SIM, EA, CA or CARV significantly decreased total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), atherogenic index, leptin and increased high density lipoprotein (HDL-c) and adiponectin. Moreover, combination of EA, CA or CARV with SIM potentiated the hypolipidemic effect of SIM and significantly ameliorated simvastatin-induced liver and muscle injury by reducing the level of alanine amiotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) and myoglobin and restoring the normal histological picture of both liver and muscle as well as decreased caspase 3 immunoreactivity

Issued also as CD

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