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Utility of image analysis and racemase immunohistochemical stain in differentiating urothelial carcinoma in-situ from its mimics : A comparative study with the triple stain cytokeratin20, CD 44 and P53 / Zahraa Shafik Mohamed Elalfy ; Supervised Elia Anis Ishak , Wafaa Elsayed Abdelaal , Samira Abdallah Mahmoud

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zahraa Shafik Mohamed Elalfy , 2018Description: 250 P. : charts , facsimiles ; 25cmOther title:
  • إستخدام تحليل الصورة وصبغة الراسيماز المناعية الهيستوكيميائية في تفرقة السرطان الموضعي للبطانة البولية عن متشابهاته : دراسة مقارنة مع الصبغة الثلاثية سيتوكيراتين 20: سي دي44 و بي 53 [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Urothelial CIS represents a neoplastic flat lesion in which the surface epithelium contains cells showing high-grade cytologic atypia. In daily practice, the conventional histologic differentiation between CIS and non-CIS conditions of the urothelial mucosa (dysplasia and reactive atypia) may be challenging. However, pathologic classification is crucial in terms of clinical management and prognosis (McKenney et al., 2001 a and b). It is prognostically and therapeutically significant; it may be very difficult to distinguish it from other lesions with considerable histomorphologic overlap (Aron et al., 2013; Oliva et al., 2013). Each lesion is defined with precise nomenclature and strict morphologic criteria. In many cases, morphologic features alone suffice for diagnosis. Other cases may require a panel of immunohistochemical antibodies consisting of cytokeratin 20 (CK20), CD44, and P53 for diagnosis. Molecular studies have provided further insight into the premalignant potential of these urothelial lesions (Hodges et al., 2010).Several studies have investigated the triple immunohistochemical staining of CK20, CD 44, and P53 in normal urothelium and flat lesions of the transitional epithelium, however, the necessity of extremely high quality staining techniques, the increased expenses and difficulty to interpret the results, remains a big obstacle for this panel to be considered as routine investigation (VandenBoom et al., 2014).A number of tumor markers have been studied for their potential role in the diagnosis and prognosis of these lesions. Nevertheless, there is still a need for more biomarkers that can identify lesions with a high risk of progression (Culhaci et al., 2010)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2018.Za.U (Browse shelf(Opens below)) Not for loan 01010110076088000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2018.Za.U (Browse shelf(Opens below)) 76088.CD Not for loan 01020110076088000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Urothelial CIS represents a neoplastic flat lesion in which the surface epithelium contains cells showing high-grade cytologic atypia. In daily practice, the conventional histologic differentiation between CIS and non-CIS conditions of the urothelial mucosa (dysplasia and reactive atypia) may be challenging. However, pathologic classification is crucial in terms of clinical management and prognosis (McKenney et al., 2001 a and b). It is prognostically and therapeutically significant; it may be very difficult to distinguish it from other lesions with considerable histomorphologic overlap (Aron et al., 2013; Oliva et al., 2013). Each lesion is defined with precise nomenclature and strict morphologic criteria. In many cases, morphologic features alone suffice for diagnosis. Other cases may require a panel of immunohistochemical antibodies consisting of cytokeratin 20 (CK20), CD44, and P53 for diagnosis. Molecular studies have provided further insight into the premalignant potential of these urothelial lesions (Hodges et al., 2010).Several studies have investigated the triple immunohistochemical staining of CK20, CD 44, and P53 in normal urothelium and flat lesions of the transitional epithelium, however, the necessity of extremely high quality staining techniques, the increased expenses and difficulty to interpret the results, remains a big obstacle for this panel to be considered as routine investigation (VandenBoom et al., 2014).A number of tumor markers have been studied for their potential role in the diagnosis and prognosis of these lesions. Nevertheless, there is still a need for more biomarkers that can identify lesions with a high risk of progression (Culhaci et al., 2010)

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