Frequency, causative organisms, and treatment of cholangitis following kasai portoenterostomy in patients with biliary atresia / Shorouk Abdelrahman Abdelazeem Osman ; Supervised Mona Elsaid Elraziky , Engy Adel Mohamed Mogahed , Noha Salah Eldein Elsayed

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Biliary atresia (BA) is the main cause of neonatal cholestasis and the primary reason for infant liver transplants worldwide. It is an obliterative cholangiopathy caused by progressive inflammation and fibrosis of the bile duct. Hepatic portoenterostomy (HPE) is the current surgical management of BA. Cholangitis is one of the main complication of BA in 30-60% of patients, most of the attacks of cholangitis occurre in the 1st two years after HPE. It manifests by fever, acholic stool, abdominal pain with or without jaundice, and positive blood culture ruling out other causes of infection. Aim of work: To assess the frequency of post operative cholangitis in patients with BA who presented to the pediatric hepatology unit, new children{u2019}s hospital, Cairo university and underwent HPE. And to detect the risk factors and causative organisms and asses different therapeutic protocols of cholangitis. Patients and methods: This retrospective study involved 40 cases who had histopathological evidence of BA, underwent HPE during the time period from January 2014 till December 2015 and followed up for at least 6 months. Several visits to the archive of the hepatology clinic, the inpatient department as well as microbiology and chemical labs have been made and the data about the cases were retrieved from the selected files

Issued also as CD