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Role of interleukin 10 gene (-1028G/A) and interleukin 12B gene (-1188A/C) and polymorphisms in hepatitis C viral clearance in Egyptian hemodialysis patients / Mahmoud Mohamed Said ; Supervised Sherif Mohamed Yousry , Hend Nabil Ellithy , Omar Mohamed Sabry

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mahmoud Mohamed Said , 2018Description: 149 P. : charts , facsimiles ; 25cmOther title:
  • في التخلص التلقائى من الالتهاب الكبدي الوبائى سى في مرضى الغسيل الكلوى المصريينb12 دور التنوع الشكلي لجينات الأنترلوكين 10 و الانترلوكين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Hepatitis C virus has been recognized as the major cause of acute and chronic hepatitis among patients with end ESRD undergoing HD, although the prevalence of the infection differs among countries and regions, the seroprevalence in HD patients in Egypt is significantly higher. It is estimated to be 52.1% in Egypt. The natural outcome of HCV infection varies dramatically among individuals, including spontaneous clearance in a minority and persistent infection for the most patients which may progress to cirrhosis, eventually hepatocellular carcinoma. Although the determinants of susceptibility to infection, self-limiting or development of chronicity have not been well defined, many investigators have drawn attention to the significance of immune-related genes. The aim of the present study is to determine the genotypes and alleles frequencies of interleukin 12ß -1188A/C (rs 3212227) gene and interleukin 10 -1028G/A (rs 1800896) gene polymorphisms among the Egyptian hemodialysis patients to assess whether these genes have a role on natural outcome of hepatitis C viral infection
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2018.Ma.R (Browse shelf(Opens below)) Not for loan 01010110076311000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2018.Ma.R (Browse shelf(Opens below)) 76311.CD Not for loan 01020110076311000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Hepatitis C virus has been recognized as the major cause of acute and chronic hepatitis among patients with end ESRD undergoing HD, although the prevalence of the infection differs among countries and regions, the seroprevalence in HD patients in Egypt is significantly higher. It is estimated to be 52.1% in Egypt. The natural outcome of HCV infection varies dramatically among individuals, including spontaneous clearance in a minority and persistent infection for the most patients which may progress to cirrhosis, eventually hepatocellular carcinoma. Although the determinants of susceptibility to infection, self-limiting or development of chronicity have not been well defined, many investigators have drawn attention to the significance of immune-related genes. The aim of the present study is to determine the genotypes and alleles frequencies of interleukin 12ß -1188A/C (rs 3212227) gene and interleukin 10 -1028G/A (rs 1800896) gene polymorphisms among the Egyptian hemodialysis patients to assess whether these genes have a role on natural outcome of hepatitis C viral infection

Issued also as CD

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