Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology

Purpose: Bone marrow biopsy (BMB) is the standard procedure to detect bone marrowinvolvement in pediatric Hodgkin lymphoma (HL).The role of [18F]{uFB02}uorodeoxyglucose positron emission tomography/computed tomography (FDG-PET) is increasing for the initial staging of HL. We assessed whether routine BMB remains necessary with concomitant FDG-PET/CT. Methods:This retrospective analysis included advanced stage pediatric HL patients over a 6-year period extending from January 2010 till the end of December 2015.BMB results were correlated with FDG-PET/CT findings. Results:The study included 64 advanced stage pediatric HL, their PET/CT scans were positive for Bone marrow(BM) involvement in 35(54.7%) patients and negative in 29(45.3%) patients. BMB results were positive in 14 of 64 patients, only eight of them were identi{uFB01}ed by PET/CT. PET/CT had a sensitivity of 57.1% and a specificity of 46.0%. The positive predictive value was 22.9%, the negative predictive valuewas 79.3%, and the overall diagnostic accuracy was 48.4%. The median follow upwas around 28 months. There was no statistical difference in EFS between (BMB- PET/CT+) and (BMB+ PET/CT-) groups, (72.5% and 50%respectively, P value=0.41). There was no statistical difference in OS between (BMB- PET+) and (BMB+ PET/CT-) groups, (59.3% and 100% respectively, P value= 0.8). EFS didn{u2019}t show significant difference between PET positive (72%)and PET negative patients (76%), (P value = 0.37), but OS was 68.8% for PET positive and 96.6% for PET negative patients (P value= 0.06)

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