header
Image from OpenLibrary

The effects of antihypertensive agents on central blood pressure measured by automated blood pressure device in hypertensive Egyptian patients / Ammar Mohammed Alnoami ; Supervised Amr Elfaramawy , Heba Moustafa Eldeeb , Dalia Elremisy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ammar Mohammed Alnoami , 2018Description: 105 P. : facsimiles ; 25cmOther title:
  • قياس تأثير أدوية إرتفاع ضغط الدم باستخدام جهاز ضغط الدم التتابعي لمرضى إرتفاع ضغط الدم المصريين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology Summary: Hypertension is a major risk factor for cardiovascular morbidity and mortality. Central blood pressure (CBP) has been shown to be more predictive of outcome than the peripheral BP. Automated office BP (AOBP) technique has several advantages over manual BP Aim of the work: The aim of our study is to evaluate the effect of representatives of the three major classes of antihypertensive drugs on CBP using AOBP measurement Methodology: A total of 90 hypertensive patients were divided into three equal groups: Group (A) received an angiotensin converting enzyme inhibitor [ACEi] (Enalapril), Group (B) received an angiotensin receptor blocker [ARBs] (Losartan), and Group (C) received a calcium channel blocker [CCB] (Amlodipine). Patients were enrolled from the Specialized Hypertension Clinics. Office BP was measured using a digital device (Omron-6 automated device), CBP was measured using AOBP device (The Mobil-O-Graph). The measurements were taken at baseline and after control of BP to goal (2 weeks up to 2 months) Results: We enrolled 90 patients with mean age of 54.6 ± 12.2 years, 38 (42.2. %) patients were males. SBP measurements were significantly higher in the office readings compared to both the sequential and the CBP with a P value < 0.001. At follow up, Group A showed the highest magnitude of reduction of central SBP [(20.7 ±11.4) mmHg vs group B (17.9 ±3.2) mmHg vs group C (14.4 ±8.8) mmHg, P value < 0.02] and central DBP (17.4 ±11.4) mmHg vs group B (11.1 ±2.3) mmHg vs group C (9.8 ±9.0)mmHg, P value < 0.002]. Conclusion: There are important differences between the classes of antihypertensive drugs regarding their effects on BP. ACE inhibitors have a more beneficial effect on reduction of CBP
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.M.Sc.2018.Am.E (Browse shelf(Opens below)) Not for loan 01010110076388000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.M.Sc.2018.Am.E (Browse shelf(Opens below)) 76388.CD Not for loan 01020110076388000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology

Hypertension is a major risk factor for cardiovascular morbidity and mortality. Central blood pressure (CBP) has been shown to be more predictive of outcome than the peripheral BP. Automated office BP (AOBP) technique has several advantages over manual BP Aim of the work: The aim of our study is to evaluate the effect of representatives of the three major classes of antihypertensive drugs on CBP using AOBP measurement Methodology: A total of 90 hypertensive patients were divided into three equal groups: Group (A) received an angiotensin converting enzyme inhibitor [ACEi] (Enalapril), Group (B) received an angiotensin receptor blocker [ARBs] (Losartan), and Group (C) received a calcium channel blocker [CCB] (Amlodipine). Patients were enrolled from the Specialized Hypertension Clinics. Office BP was measured using a digital device (Omron-6 automated device), CBP was measured using AOBP device (The Mobil-O-Graph). The measurements were taken at baseline and after control of BP to goal (2 weeks up to 2 months) Results: We enrolled 90 patients with mean age of 54.6 ± 12.2 years, 38 (42.2. %) patients were males. SBP measurements were significantly higher in the office readings compared to both the sequential and the CBP with a P value < 0.001. At follow up, Group A showed the highest magnitude of reduction of central SBP [(20.7 ±11.4) mmHg vs group B (17.9 ±3.2) mmHg vs group C (14.4 ±8.8) mmHg, P value < 0.02] and central DBP (17.4 ±11.4) mmHg vs group B (11.1 ±2.3) mmHg vs group C (9.8 ±9.0)mmHg, P value < 0.002]. Conclusion: There are important differences between the classes of antihypertensive drugs regarding their effects on BP. ACE inhibitors have a more beneficial effect on reduction of CBP

Issued also as CD

There are no comments on this title.

to post a comment.