Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic fat infiltration by >5% of hepatocytes, as assessed by liver biopsy, NAFLD is now considered the most prevalent form of chronic liver disease, affecting approximately 10%{u2013}20% of the general pediatric population. Aim of work: The aim of this study was to determine prevalence of each of the causes of secondary NAFLD. Patients and methods:A final number of 66 patients presented with biopsy proven macrovesicularsteatosis in the period from 2010{u2013} 2015 to the Pediatric Hepatology Unit, Cairo University , Children's Hospital, whom their data were retrospectively analyzed for the etiology, clinical presentation, history, initial laboratory investigations, abdominal ultrasonography and their biopsy data. Results: The median age of presentation was 2.7 years with more prevalence in boys (65.2%),the commonest presentation was abdominal distention (69.7%).Biopsy revealed preserved lobular architecture in 50 biopsies (75.7%).The inflammation and fibrosis were mainly in the portal areas (90.9%). The study revealed that the commonest diagnosis was GSD (33.3%) followed by HCV infection (10.6%) then Chanrin-dormann syndrome 9.1%. Conclusion:There is a higher prevalence of secondary causes of NAFLD in patients younger than 10 years old, with higher degree of steatosis in younger patients and chanarindorfmann patients show more fibrosis and steatosis than other diagnoses. In this study GSD was the commonest cause of secondary NAFLD

Issued also as CD