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The role of magnetic resonance imaging in the assessment of iron overload in chronically transfused patients with sickle cell anemia and thalassemia major / Gehad Ramadan Hassanein ; Supervised Hadeel Mohammed Seif , Amina Abdelsalam Mahmoud , Rania Zakaria Hasan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Gehad Ramadan Hassanein , 2018Description: 128 P. : charts , facsimiles ; 25cmOther title:
  • دور التصوير بالرنين المغناطيسى فى تقييم تراكم الحديد الناتج عن نقل الدم المتكرر لمرضي أنيميا البحر الأبيض المتوسط و أنيميا الخلايا المنجلية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis Summary: Objectives & aim of work : To assess role of magnetic resonance imaging (MRI) T2* technique in the evaluation of iron distribution between liver, pancreas and myocardium in chronically transfused patients with sickle cell anemia and thalassemia major and its correlation to serum ferritin. Background: Patients with thalassemia major and sickle cell anemia need repeated blood transfusions which lead to iron overload especially in the heart and liver and endocrine system. Classically, serum ferritin and liver biopsy have been used to monitor patient response to chelation therapy. Magnetic resonance imaging (MRI) has been proved effective in detecting and quantifying iron in the heart, liver and pancreas. Methods: In 60 cases of monthly transfused patients, hepatic, myocardial and pancreatic iron overload was measured by MRI T2* and compared to serum ferritin (a traditional marker of iron overload). Results: No significant correlation was observed between serum ferritin level and cardiac T2* MRI (p= 0.168). No significant correlation was observed between serum ferritin and liver T2* MRI (p= 0.102). No significant correlation was observed between serum ferritin and pancreatic T2* MRI (p= 0.210). Conclusion: MRI T2* is better for assessment of iron overload in chronically transfused patients with thalassemia and sickle cell anemia
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.31.M.Sc.2018.Ge.R (Browse shelf(Opens below)) Not for loan 01010110076479000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.31.M.Sc.2018.Ge.R (Browse shelf(Opens below)) 76479.CD Not for loan 01020110076479000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis

Objectives & aim of work : To assess role of magnetic resonance imaging (MRI) T2* technique in the evaluation of iron distribution between liver, pancreas and myocardium in chronically transfused patients with sickle cell anemia and thalassemia major and its correlation to serum ferritin. Background: Patients with thalassemia major and sickle cell anemia need repeated blood transfusions which lead to iron overload especially in the heart and liver and endocrine system. Classically, serum ferritin and liver biopsy have been used to monitor patient response to chelation therapy. Magnetic resonance imaging (MRI) has been proved effective in detecting and quantifying iron in the heart, liver and pancreas. Methods: In 60 cases of monthly transfused patients, hepatic, myocardial and pancreatic iron overload was measured by MRI T2* and compared to serum ferritin (a traditional marker of iron overload). Results: No significant correlation was observed between serum ferritin level and cardiac T2* MRI (p= 0.168). No significant correlation was observed between serum ferritin and liver T2* MRI (p= 0.102). No significant correlation was observed between serum ferritin and pancreatic T2* MRI (p= 0.210). Conclusion: MRI T2* is better for assessment of iron overload in chronically transfused patients with thalassemia and sickle cell anemia

Issued also as CD

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