A comparative study for the anti-inflammatory effect of low level laser therapy and corticosteroids on induced osteoarthritis of temporomandibular joint in albino rats : An animal study / Nermeen Mohamed Abubakr Mohamed Tawfik Amin ; Supervised Manal Mostafa Safwat Elassly , Zoba Hassan Ali , Zainab Amin Ibrahim

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine- Department of Oral Biology

Background: Osteoarthritis (OA) is one of the most common temporomandibular degenerative disorders. It showed a higher prevalence in women and older age groups. Due to the increasing prevalence and absence of cure for OA, it became a serious health economic burden for the nations. Thus, there is a pressing socioeconomic need for extensive improvements in the prevention and treatment of the disease. Aim of the study: This study aimed to investigate and compare between the anti-inflammatory effect of low level laser (LLL) contra corticosteroids on induced OA in TMJ of Albino rats. Methods: 96 adult female Albino rats weighing about 180-200g were used. Animals received a single intar-articular (IA) injection of 2 mg/kg monosodium iodoacetate to induce OA. Group Ї, the positive control group. Group ЇЇ received seven sessions of 60s LLLT performed every other day for 2-weeks. Group ЇЇЇ was given a single IA injection of 1.2mg/kg dexamethasone. Half of the animals in each group were sacrificed at 1& 4 weeks post treatment. Results: Histopathological examination of rat TMJ revealed degenerative changes and loss of the normal architecture in the osteoarthritic group. These degenerative changes decreased in both treated groups. Safranin-O stain showed obvious reduction and generalized loss in proteoglycans staining in the osteoarthritic group. However, there was a uniform moderate increase in GAGs staining in both treated groups. As for the Masson trichrome stain, collagen formation in the treated groups was higher than that in OA group

Issued also as CD