Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology

Background: Skin wound healing is a dynamic process which affected by many factors (Guo and dipietro, 2010). This process has been associated with reduced endogenous growth factors levels or activity in the wound site. Among the factors involved in the process of wound healing, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have been shown to play key roles (Lerman, Galiano, Armour, Levine, and Gurtner, 2003). If impaired healing of the skin taking more than 8 weeks it will lead to chronic a wound (Moulik, mtonga, and Gill, 2003). Tissue engineering for regenerative skin tissue had several advantages to help in faster wound healing and restoring the skin (Chaudhari, et al., 2016). Scaffolds serve as a replacement to the natural extracellular matrix (ECM) until host cells could repopulate and synthesize a new natural matrix. Many biodegradable materials have been used to fabricate scaffolds; these materials include poly (lactic acid) (PLA) and others (Mohanraj, Sethuraman and Krishnan, 2013; Doğan, et al., 2014). PLA is the only member of the polyester family that has been used for load bearing applications, owing to the high mechanical strength (Chu, et al., 2010). Objectives: This study was conducted to use unloaded PLA scaffold material contra to PLA loaded with bFGF in stimulating the regenerative potentials of subcutaneous soft tissue defect. This approach could help in restoring, maintaining, or improving tissue functions that are defective or have been lost by different pathological conditions

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