The relation betweenserum neuropeptide Y levels and asthma in Egyptian asthmatic children / Ashraf Ismail Mohamed Hasan ; Supervised Hala Hamdy Shaaban , Noussa Ragab Mohamed , Amaal Abdo Abdelaal

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Objective: The aim of this study is to determine the association between the serum level of neuropeptide Y and asthma and to be correlated with the severity of asthma according to Global initiative for asthma guidelines. Background:Asthma is a highly prevalent chronic respiratory disease affecting 300 million people world-wide. Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity Methods: This study was conducted on 60 pediatric patients, who fulfilled the criteria for diagnosis of bronchial asthma according to Global Initiative of Asthma, GINA Guidelines (2011). An additional 30 age and sex matched healthy children were served as a control group. Controls and patients of the present study were subjected to clinical evaluation and laboratory investigations in the form of complete blood count and Neuropeptide Y level measurement Results: 70% of the patients were male while 30% of the patients were female. The mean age was 6.6 ± 3.2 years in asthmatic patients and 6.1 ± 3.2 years in control. 46.67% of the patients and 56.67% of the control inhabit in an urban area. According to GINA, intermittent asthma was found in 16.67% of the patients while persistent asthma was found mildly in 31.67%, moderately in 35% and severely in 16.67% of the patients.The asthma duration ranged from one month to 132 months with a mean of 57.58 ± 42.86 months

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