Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

This study was conducted at Cairo University Obstetrics and Gynecology hospital IVF unit from February 2015 to October 2017; the study included 80 poor responder patients undergoing ICSI. Objectives: To investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) can improve number of retrieved oocytes and clinical pregnancy rate in poor responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles. Methods: 80 Poor responders to controlled ovarian hyper stimulation patients who were undergoing IVF-ICSI with a GnRH antagonist protocol, then divided into two groups:Study group: 40 patients who will receive 10000 unit of HCG (choriomon ®, IBSA 10000 IU) plus 0.2 mg of triptorelin (Decapeptyl).Control group: 40 patients who receive Standard dosage of hCG trigger (10000 unit of HCG (choriomon ®, IBSA 10000 IU)). Then: 1- Number of retrieved oocytes, number of MII oocytes, number of embryos obtained and number of embryos transferred will be detected in patients of both groups.2- Implantation rate, clinical pregnancy rate will be detected in patients of both groups. Results: Dual trigger improve the number of retrieved oocytes, MII oocytes, number of embryos obtained and number of embryos transferred. Dual trigger has higher pregnancy and implantation rate but the results in our study were not statistically significant

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