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Neurobehavioral and neurochemical changes caused by Co-administration of tramadol with other drugs of abuse in experimental animals / Shimaa Mohamed Azmy Mohamed ; Supervised Eldin Said Eldenshary , Noha Nagah Nassar , Somia Ahmed Nada

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shimaa Mohamed Azmy Mohamed , 2018Description: 168 P. : charts , facsimiles ; 25cmOther title:
  • التغيرات السلوكية العصبية و الكيميائية العصبية التى يسببها التناول المتزامن للترامادول مع أدويه الإدمان الأخرى فى حيوانات التجارب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls. Increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa B and the proinflammatory cytokine tumor necrosis factor Ü with the induction of apoptosis evident by the increased caspase-3 immunoreactivity
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2018.Sh.N (Browse shelf(Opens below)) Not for loan 01010110077230000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.Ph.D.2018.Sh.N (Browse shelf(Opens below)) 77230.CD Not for loan 01020110077230000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls. Increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa B and the proinflammatory cytokine tumor necrosis factor Ü with the induction of apoptosis evident by the increased caspase-3 immunoreactivity

Issued also as CD

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