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A pharmaceutical study on certain vesicular carriers for transdermal delivery of a certain anti-hypertensive drug / Mai Magdy Abdelfatah ; Supervised Mohamed Aly Kassem , Mona Hassan AboEleinien

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Magdy Abdelfatah , 2018Description: 158 P. : charts , facsimiles ; 25cmOther title:
  • دراسة صيدلية على حويصلات معينة لتوصيل دواء خافض لضغط الدم معين عبر الجلد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The first-pass effect (known as first-pass metabolism or presystemic metabolism) is a phenomenon in which the orally administered drug is metabolized in either the liver or the gastrointestinal tract before it reaches the systemic circulation resulting in a reduced bioavailability which in turn affects the drug therapeutic efficacy (George,C.1979). Felodipine is a dihydropyridines calcium channel blocker which is used in the treatment of hypertension and angina pectoris. It is almost completely absorbed from the gastrointestinal tract after oral administration but undergoes extensive first-pass metabolism, with a bioavailability of about 15% (range 10 to 25%); so, transdermal drug delivery could be suitable for felodipine as noninvasive pathway to enhance the bioavailability. Transdermal route for drug administration manifests definite advantages in the context of being user friendly and noninvasive, but its utilization has been hampered by naturally occurring protective barrier properties of the skin, especially the stratum corneum. Hence, the major emphasis of research related to transdermal delivery of felodipine has focused on overcoming the permeation difficulties utilizing different approaches
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2018.Ma.P (Browse shelf(Opens below)) Not for loan 01010110077234000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2018.Ma.P (Browse shelf(Opens below)) 77234.CD Not for loan 01020110077234000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The first-pass effect (known as first-pass metabolism or presystemic metabolism) is a phenomenon in which the orally administered drug is metabolized in either the liver or the gastrointestinal tract before it reaches the systemic circulation resulting in a reduced bioavailability which in turn affects the drug therapeutic efficacy (George,C.1979). Felodipine is a dihydropyridines calcium channel blocker which is used in the treatment of hypertension and angina pectoris. It is almost completely absorbed from the gastrointestinal tract after oral administration but undergoes extensive first-pass metabolism, with a bioavailability of about 15% (range 10 to 25%); so, transdermal drug delivery could be suitable for felodipine as noninvasive pathway to enhance the bioavailability. Transdermal route for drug administration manifests definite advantages in the context of being user friendly and noninvasive, but its utilization has been hampered by naturally occurring protective barrier properties of the skin, especially the stratum corneum. Hence, the major emphasis of research related to transdermal delivery of felodipine has focused on overcoming the permeation difficulties utilizing different approaches

Issued also as CD

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