Ultrasound guided thoracic paravertebral block double blind randomized controlled study using dexmeditomedine versus clonidine with levobupivacaine in postoperative analgesia for acute post mastectomy pain / Sally Mostafa Hamed ; Supervised Sahar Abdelhalim Tawfik , Maha Abdelwahab Abdelaleem , Mohamed Mahmoud Hassan

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Anaesthesia and Pain Relief

Backgroud: Acute postoperative pain is an important problem after radical mastectomy also a risk factor for development of postmastecomy pain syndrome. Treatment of postoperative pain following mastectomy is an area of increasing interest as this treatment option is now considered a standard of care for those affected by breast cancer. The objective of our study is to compare the effect of addition of either dexmedetomidine or clonidine to levobupivacaine for augmentation of local anesthetic action and prolongation of analgesia time. Methodology: 126 patients were divided randomly by computer randomization program into 3 groups 42 patients each. Group L received 20 mL of 0.25% levobupivacaine alone. Group LD received dexmedetomedine (1mic/kg) added to 20 mL 0.25% levopubivacaine. Group LC received clonidine (1mic/kg) added to 20 mL 0.25% levopubivacaine. These injected into paravertebral space at T3 level under U/S guidance after finishing surgery while patient still under GA. Heart rate, systolic blood pressure, diastolic blood pressure, sedation score, modified VAS, analgesia time, and analgesic requirements were followed

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