Analytical study on some amide-containing drugs / Sara Abdelrasheed Elhanboushy ; Supervised Mohamed Abdelkawy , Hayam Mahmoud Lotfy , Yasmin Mohamed Fayez

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This thesis consisted of a medical introduction and two chapters: Part I: Simultaneous determination of PSE, LOR in their binary mixture and with PAR in their ternary mixture in trimed Flu® and Clarinase® tablets: This part was divided into five sections: Section A: General introduction and literature review: This section provided a general introduction about the chemistry, mode of action and literature review of the reported analytical methods of PSE, LOR and PAR. Section B: Spectrophotometric methods for determination of co-formulated drugs of PSE, LOR and PAR in presence of PAP: This section consists of two parts: I.B.1.Simultaneous determination of PSE and LOR in their binary mixture and with PAR in their ternary mixture in presence of PAP by spectrophotometric methods via different manipulation pathways Different manipulating pathways were applied for simultaneous determination of mixtures of PSE, LOR and PAR in presence of PAP (the degradation product of PAR) in their pure powdered form and pharmaceutical dosage form. PAP could be eliminated first by constant multiplication method to give resolved ternary mixture of PSE, LOR and PAR

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