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Early results & complications of asct in hematological malignancies / Hagar Hamdy Abdelhady Mahmoud ; Supervised Hamdy Mohamad Zawam , Nermeen Ahmad Eldesouky , Rasha Salama

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hagar Hamdy Abdelhady Mahmoud , 2018Description: 171 P. : charts ; 25cmOther title:
  • دراسه النتائج الأوليه و المضاعفات لزرع النخاع الذاتى فى اورام الدم [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical-Oncology Summary: Objectives: This is a cross sectional observational study done on 25 patients of MM and lymphoma who underwent ASCT at NEMROCK aiming to assess the early results and complications.Methods: Twenty five patients with MM and chemosensitive lymphoma underwent ASCT (one case was excluded during conditioning). All patients were younger than 65 years old and met the eligibility criteria for ASCT at the NEMROCK. Results: Three regimens were used for mobilization; HD endoxan, HD chemotherapy and plerixafor. There was no significant difference in the yield between the 3 regimens. The amount of stem cell yield was higher in cases of MM than lymphoma. Failure of mobilization developed in 8.3% of cases. In a trial to decrease the complications encountered during mobilization; the dose of endoxan was reduced without affecting the stem cell yield yet decreasing the platelets and PRBCS requirements. Neutropenic fever developed in 50% of cases and was controlled in most cases on D2.Other complications seen were; diarrhea GI-II (54%), nausea GI (29%), oral mucositis GII (12.5%), permicath infection (12.5%) and vomiting GI (4.1%).The early results showed that 19 patients are still under follow. One patient has relapsed and still alive and 4 patients have died (3 due to DP and 1 due to TRM
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2018.Ha.E (Browse shelf(Opens below)) Not for loan 01010110077322000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2018.Ha.E (Browse shelf(Opens below)) 77322.CD Not for loan 01020110077322000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical-Oncology

Objectives: This is a cross sectional observational study done on 25 patients of MM and lymphoma who underwent ASCT at NEMROCK aiming to assess the early results and complications.Methods: Twenty five patients with MM and chemosensitive lymphoma underwent ASCT (one case was excluded during conditioning). All patients were younger than 65 years old and met the eligibility criteria for ASCT at the NEMROCK. Results: Three regimens were used for mobilization; HD endoxan, HD chemotherapy and plerixafor. There was no significant difference in the yield between the 3 regimens. The amount of stem cell yield was higher in cases of MM than lymphoma. Failure of mobilization developed in 8.3% of cases. In a trial to decrease the complications encountered during mobilization; the dose of endoxan was reduced without affecting the stem cell yield yet decreasing the platelets and PRBCS requirements. Neutropenic fever developed in 50% of cases and was controlled in most cases on D2.Other complications seen were; diarrhea GI-II (54%), nausea GI (29%), oral mucositis GII (12.5%), permicath infection (12.5%) and vomiting GI (4.1%).The early results showed that 19 patients are still under follow. One patient has relapsed and still alive and 4 patients have died (3 due to DP and 1 due to TRM

Issued also as CD

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