Healing of periapical lesions using triple antibiotic paste versus calcium hydroxide as root canal disinfectant : A randomized clinical trial / Ehab Abdelhamid Ahmed ; Supervised Saied Mohamed Abdelaziz , Hany Samy Sadek

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Endodontics

A parallel randomized clinical trial to answer a clinical question in patients with periapical lesions would triple antibiotic paste root canal disinfectant in comparison to calcium hydroxide root canal disinfectant differ in postoperative pain and periapical healing. Thirty-eight medically free participants who had non-vital single rooted teeth with radiographic evidence of periapical lesions (minimum size 2.0 mm {u00D7} 2.0 mm) were randomly assigned into two equal groups according to the root canal disinfectant to be used, either calcium hydroxide (group A), or triple antibiotic paste (group B). Root canal treatment was completed in two visits; in the first visit root canal shaping and cleaning was performed, root canal disinfectant placed, and each participant was scheduled for a second appointment to complete root canal therapy after 2 weeks. Postoperative pain was measured using a numerical rating scale (NRS) at 4, 24, 48, 72 and 96 hours after initial visit. Healing of periapical lesion was assessed using densitometric analysis at the following periods 3, 6, 9, 12 months. Results showed that through the whole study period; there was no statistically significant difference between mean pain scores in the two groups, also there was no statistically significant difference between healing in the two groups. It could be concluded that the use of root canal disinfectant either calcium hydroxide or triple antibiotic paste in non-vital teeth with periapical lesions reduced postoperative pain. Also, Periapical lesions responded favorably to non-surgical root canal treatment using either calcium hydroxide or triple antibiotic paste as root canal disinfectant

Issued also as CD