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Study of pharmaceutical and photodynamic efficiency of curcumin in drug delivery systems / Nayera Mohamed Ali Elghoubary ; Supervised Maha Fadel Mohamed , Doaa Ahmed Abdelfadeel

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nayera Mohamed Ali Elghoubary , 2018Description: 96 P. : charts , photographs ; 25cmOther title:
  • دراسة الكفاءة الصيدلية و الكفاءة الضوئية الديناميكية للكركم فى موصلات الدواء [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applications in Medical and Biological Summary: Curcumin is a natural pigment that generates singlet oxygen upon light excitation; hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study two different delivery systems for curcumin were prepared: liposomes and PVP gold nanoparticles. Cur liposomes were prepared by lipid film hydration method. PVP capped gold nanoparticles were prepared using chloroauric acid as a metal precursor and trisodium citrate. The results showed that the Cur liposomes were spherical in shape of size 350±94 nm and uniform size distribution, had high encapsulation efficiency. Also, the results of Cur PVP gold nanoparticles showed that they were spherical in shape of size 23±2.22 nm. The UV-Vis spectrum of Cur PVP GNPs which shows two peaks, the first one at 408 nm and the second one at 525nm which confirms the characteristic peaks for the components in the Cur PVP GNPs complex are intact. In the FTIR spectrum of Cur conjugated with PVP capped gold nanoparticles, there is a shift of O-H (hydroxyl group)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.M.Sc.2018.Na.S (Browse shelf(Opens below)) Not for loan 01010110077469000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.M.Sc.2018.Na.S (Browse shelf(Opens below)) 77469.CD Not for loan 01020110077469000

Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applications in Medical and Biological

Curcumin is a natural pigment that generates singlet oxygen upon light excitation; hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study two different delivery systems for curcumin were prepared: liposomes and PVP gold nanoparticles. Cur liposomes were prepared by lipid film hydration method. PVP capped gold nanoparticles were prepared using chloroauric acid as a metal precursor and trisodium citrate. The results showed that the Cur liposomes were spherical in shape of size 350±94 nm and uniform size distribution, had high encapsulation efficiency. Also, the results of Cur PVP gold nanoparticles showed that they were spherical in shape of size 23±2.22 nm. The UV-Vis spectrum of Cur PVP GNPs which shows two peaks, the first one at 408 nm and the second one at 525nm which confirms the characteristic peaks for the components in the Cur PVP GNPs complex are intact. In the FTIR spectrum of Cur conjugated with PVP capped gold nanoparticles, there is a shift of O-H (hydroxyl group)

Issued also as CD

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