Clinical and radiographic evaluation of recombinant human platelet-derived growth factor and beta tricalcium phosphate for the treatment of periodontal intraosseous defects / Yasmine Mohamed Fathy Mahmoud ; Supervised Azza Mohamed Ezz Elarab , Manal Mohamed Hosny , Mohamed Khalifa

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

The present investigation was conducted to evaluate the clinical and radiographic regenerative effect of Recombinant Human Platelet {u2013} Derived Growth Factor and Beta Tricalcium Phosphate (GEM 21S) for the treatment of moderate to severe intrabony periodontal defects in humans. The study was performed on ten medically free patients (7 females and 3 males), age range (24-58) having periodontitis with intraosseous defects. Clinical parameters were recorded after the initial phase of plaque control. Radiographic linear and densitometric measurements were performed by the direct digital radiography pre-surgically (Baseline). Open flap debridement (Access Flap) with scaling and root planing was performed in management of these patients. Ten intrabony defects (Test group) were treated with highly purified rhPDGF (0.5 mL 0.3 mg/mL) and synthetic Ý-TCP (0.5 cc) Ca₃ [PO₄) (GEM 21S®), while the other ten defects were treated with Ý-TCP only (Ý-TCP was mixed with saline). The same initial clinical parameters and radiographic measurements were recorded at nine months post-surgically. The results of this study revealed that GEM 21S® led to significant improvement in clinical and radiographic parameters throughout the whole experimental period. However, within Ý-TCP group, there was no significant change in all parameters at nine months. Comparing both treatment modalities to each other after 9 months of treatment; there were significant differences in PPD, CAL and defect depth, and insignificant differences in PI, GI and bone density

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