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Preparation of horse polyvalent antiserum against rhodococcus equi and evaluation of its therapeutic and prophylactic efficacy / Shimaa Ahmed Abdelbaki ; Supervised Rafik Tawfik Mohamed Soliman , Mohamed Youssef Salah Mattok , George Abdelmalak Habib

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shimaa Ahmed Abdelbaki , 2018Description: 127 P. : facsimiles ; 25cmOther title:
  • تحضير مصل خيول متعدد ضد بكتريا الرودوكوكس اكواى و تقييم قدرته العلاجية و الوقائية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology Summary: Rhodococcus equi, a Gram-positive facultative intracellular pathogen, is among the most widely recognized causes of pneumonia in foals. Several antimicrobial drugs are effective against R. equi in vitro; however, many of these agents are ineffective in vivo because of the capability of R. equi to survive and replicates in macrophages. The present study aimed to prepare R. equi-specific hyperimmune horse antiserum and to evaluate its therapeutic and prophylactic efficacy against R. equi infection. Four horses were immunized with a locally prepared formalin inactivated R. equi vaccine adjuvanted with mineral oil. Each of these horses was immunized with 3 doses of the prepared vaccine (3ml/ dose) at 2 weeks intervals. One week after the last vaccination dose, serum from immunized horses was collected by plasmapheresis. The measured titer of R. equi specific antibodies reached to 104 ELISA units/ml after 2 weeks from the primary immunization and up to 105 ELISA units/ml one week after the third immunization dose
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.10.M.Sc.2018.Sh.P (Browse shelf(Opens below)) Not for loan 01010110077638000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.10.M.Sc.2018.Sh.P (Browse shelf(Opens below)) 77638.CD Not for loan 01020110077638000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology

Rhodococcus equi, a Gram-positive facultative intracellular pathogen, is among the most widely recognized causes of pneumonia in foals. Several antimicrobial drugs are effective against R. equi in vitro; however, many of these agents are ineffective in vivo because of the capability of R. equi to survive and replicates in macrophages. The present study aimed to prepare R. equi-specific hyperimmune horse antiserum and to evaluate its therapeutic and prophylactic efficacy against R. equi infection. Four horses were immunized with a locally prepared formalin inactivated R. equi vaccine adjuvanted with mineral oil. Each of these horses was immunized with 3 doses of the prepared vaccine (3ml/ dose) at 2 weeks intervals. One week after the last vaccination dose, serum from immunized horses was collected by plasmapheresis. The measured titer of R. equi specific antibodies reached to 104 ELISA units/ml after 2 weeks from the primary immunization and up to 105 ELISA units/ml one week after the third immunization dose

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