header
Image from OpenLibrary

New biomarkers for diabetic nephropathy in Egyptian patients with type II diabetes / Yasmin Farid Mohamed Elemady ; Supervised Tarek Mohamed Kamal Motawi , Nagwa Ibrahim Shehata , Mahmoud Mohamed Elnokeety

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Yasmin Farid Mohamed Elemady , 2018Description: 111 P. : charts ; 25cmOther title:
  • دلالات حيوية جديدة للاعتلال الكلوى المصاحب لمرض البوال السكرى من النوع الثاني فى المرضى المصريين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Aim: Diabetic nephropathy (DN) is considered as one of the diabetic complications affecting up to 40% of patients with type 1 or type 2 diabetes. In clinical practice, the frequently used markers of renal disease and progression are serum creatinine, estimated glomerular filtration rate (eGFR) and albuminuria. The aim of this study is to determine new biomarkers in human serum which are promising for early detection of DN. Methods: This study included 50 patients with type 2 diabetes mellitus (T2DM) and 25 clinically healthy individuals. The patients were divided into two groups; group I included 25 T2DM patients with normoalbuminuria, and group II consisted of 25 T2DM patients with microalbuminuria. In all groups, neutrophil gelatinase-associated lipocalin (NGAL), Ý-trace protein (ÝTP) and microRNA-130b (miR-130b) were estimated. Results: The serum levels of NGAL and ÝTP were significantly elevated in T2DM patients with microalbuminuria (group II) compared with T2DM patients with normoalbuminuria (group I) and control subjects but there was no significant difference between group I and control subjects. Serum miR-130b level was significantly decreased in patients with T2DM (groups I and II) compared with healthy control subjects, with a higher decrease in their levels in group II compared with group I
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2018.Ya.N (Browse shelf(Opens below)) Not for loan 01010110077746000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.Ph.D.2018.Ya.N (Browse shelf(Opens below)) 77746.CD Not for loan 01020110077746000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Aim: Diabetic nephropathy (DN) is considered as one of the diabetic complications affecting up to 40% of patients with type 1 or type 2 diabetes. In clinical practice, the frequently used markers of renal disease and progression are serum creatinine, estimated glomerular filtration rate (eGFR) and albuminuria. The aim of this study is to determine new biomarkers in human serum which are promising for early detection of DN. Methods: This study included 50 patients with type 2 diabetes mellitus (T2DM) and 25 clinically healthy individuals. The patients were divided into two groups; group I included 25 T2DM patients with normoalbuminuria, and group II consisted of 25 T2DM patients with microalbuminuria. In all groups, neutrophil gelatinase-associated lipocalin (NGAL), Ý-trace protein (ÝTP) and microRNA-130b (miR-130b) were estimated. Results: The serum levels of NGAL and ÝTP were significantly elevated in T2DM patients with microalbuminuria (group II) compared with T2DM patients with normoalbuminuria (group I) and control subjects but there was no significant difference between group I and control subjects. Serum miR-130b level was significantly decreased in patients with T2DM (groups I and II) compared with healthy control subjects, with a higher decrease in their levels in group II compared with group I

Issued also as CD

There are no comments on this title.

to post a comment.