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Phytochemical and biologicalstudy of madina dates (phoenixdactyliferavar. ajwah) and its phyto-nanoformulation : Potential impacton hepatic fibrosis / Khaled Ahmed Nematallah ; Supervised Meselhy Ragab Meselhy , Essam Abdelsattar , Nahla Abdelhamid Ayoub

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Khaled Ahmed Nematallah , 2018Description: 285 P. : charts ; 25cmOther title:
  • دراسة فيتوكيميائية و بيولوجية لبلح المدينة ( فونكس داكتايليفيرا صنف عجوة ) و تركيبته المتناهية الصغر : تأثيرها المحتمل على التليف الكبدى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: Ajwa fruits are among the most nutritious and economically valuable fruits. In this study, the effect of different solvents on the extraction of polyphenols was investigated. Aqueous acetone (50%)extract containedthe highest content of polyphenols and flavonoids. Filtration of the extract through a Diaion HP-20column led to a polyphenols-enriched fraction (Fr1) that had the highest antioxidant activity as measured with ORAC and DPPH assays. Metabolic profiling of the different extracts using HPLC-ESI-QTOF-MS-MS led to the tentative identification of 33 secondary metabolites: 3 phenolic acids, 19 flavonoid glycosides including 4 sulfated derivatives, 2 lignans, and 9 fatty acids. Furthermore, the hydrolysis products of Fr1were studied by HPLC-DAD-UV and revealed presence of quercetin and luteolin aglycones. Fr1showed a promising hepatoprotective activity when tested invitro utilizing HepG2 cell lines and in-vivo against thioacetamide-induced liver fibrosis in mice.Ingestion of Fr1in the form of a microemulsion had significantly higher oral bioavailability than when ingested as a suspension in water
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2018.Kh.P (Browse shelf(Opens below)) Not for loan 01010110077970000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2018.Kh.P (Browse shelf(Opens below)) 77970.CD Not for loan 01020110077970000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Ajwa fruits are among the most nutritious and economically valuable fruits. In this study, the effect of different solvents on the extraction of polyphenols was investigated. Aqueous acetone (50%)extract containedthe highest content of polyphenols and flavonoids. Filtration of the extract through a Diaion HP-20column led to a polyphenols-enriched fraction (Fr1) that had the highest antioxidant activity as measured with ORAC and DPPH assays. Metabolic profiling of the different extracts using HPLC-ESI-QTOF-MS-MS led to the tentative identification of 33 secondary metabolites: 3 phenolic acids, 19 flavonoid glycosides including 4 sulfated derivatives, 2 lignans, and 9 fatty acids. Furthermore, the hydrolysis products of Fr1were studied by HPLC-DAD-UV and revealed presence of quercetin and luteolin aglycones. Fr1showed a promising hepatoprotective activity when tested invitro utilizing HepG2 cell lines and in-vivo against thioacetamide-induced liver fibrosis in mice.Ingestion of Fr1in the form of a microemulsion had significantly higher oral bioavailability than when ingested as a suspension in water

Issued also as CD

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