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Assessment of the potential protective effect of alpha-lipoic acid against nano copper particles induced hepato and nephrotoxicity in adult male albino rats : A chronic study / Rabab Abdelmoez Amin Eltokhy ; Supervised Mervat Hamdy Abdelsalam , Eman Abdelfattah Elzohairy , Laila Ahmed Rashed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rabab Abdelmoez Amin Eltokhy , 2018Description: 173 P. : facsimiles ; 25cmOther title:
  • تقييم التأثير الوقائى المحتمل لحمض الألفا ليبويك ضد سميية الكبد و الكلى التى تحدث بواسطة جزيئات نانو النحاس فى ذكور فئران التجارب البيضاء البالغه : دراسة مزمنة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine-Toxicology Summary: Background: Copper nanoparticles received considerable attention because of their unique physical and chemical properties distinct from the bulk materials for this reason it was used in various medical and non-medical applications. Objectives: The aim of the current study is to identify the toxic effect of copper nanoparticles on liver and kidney and to study the potential protective effect of alpha lipoic acid against hepato-nephrotoxicity induced by copper nanoparticles. Animals and Methods: In the current study, 100 adult male albino rats were classified into 4 main groups: Group 1is the negative control group, group 2 was treated with CNPs and was classified into 2 subgroups one of them was to study the toxic effects of CNPs and the other was allowed to recover from CNPs toxicity for 4 weeks (follow up group), group 3 was treated with ALA and group 4 was treated with CNPs and ALA as a prophylaxis for 90 consecutive days. The study design was approved from the local ethical committee of faculty of medicine, Cairo university and from Cairo university institutional animal care and use committee (CU- IACUC), medical science sector
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.13.Ph.D.2018.Ra.A (Browse shelf(Opens below)) Not for loan 01010110077853000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.13.Ph.D.2018.Ra.A (Browse shelf(Opens below)) 77853.CD Not for loan 01020110077853000
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Cai01.11.13.Ph.D.2018.No.P The potential role of palatal rugae pattern, dental arch dimensions and maxillary canine index in sex determination among an adult Egyptian population sample / Cai01.11.13.Ph.D.2018.No.P The potential role of palatal rugae pattern, dental arch dimensions and maxillary canine index in sex determination among an adult Egyptian population sample / Cai01.11.13.Ph.D.2018.Ra.A Assessment of the potential protective effect of alpha-lipoic acid against nano copper particles induced hepato and nephrotoxicity in adult male albino rats : A chronic study / Cai01.11.13.Ph.D.2018.Ra.A Assessment of the potential protective effect of alpha-lipoic acid against nano copper particles induced hepato and nephrotoxicity in adult male albino rats : A chronic study / Cai01.11.13.Ph.D.2018.Sh.E Experimental study for identification of vaginal secretions using lactobacillus dna at different storage durations / Cai01.11.13.Ph.D.2018.Sh.E Experimental study for identification of vaginal secretions using lactobacillus dna at different storage durations / Cai01.11.13.Ph.D.2019.En.E Estimation of post-mortem interval in cardiac lesions : An immunohistochemical comparative study using C5b-9 and Cardiac Troponin C. /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine-Toxicology

Background: Copper nanoparticles received considerable attention because of their unique physical and chemical properties distinct from the bulk materials for this reason it was used in various medical and non-medical applications. Objectives: The aim of the current study is to identify the toxic effect of copper nanoparticles on liver and kidney and to study the potential protective effect of alpha lipoic acid against hepato-nephrotoxicity induced by copper nanoparticles. Animals and Methods: In the current study, 100 adult male albino rats were classified into 4 main groups: Group 1is the negative control group, group 2 was treated with CNPs and was classified into 2 subgroups one of them was to study the toxic effects of CNPs and the other was allowed to recover from CNPs toxicity for 4 weeks (follow up group), group 3 was treated with ALA and group 4 was treated with CNPs and ALA as a prophylaxis for 90 consecutive days. The study design was approved from the local ethical committee of faculty of medicine, Cairo university and from Cairo university institutional animal care and use committee (CU- IACUC), medical science sector

Issued also as CD

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