Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Objectives: The aim of the present study was to evaluate the possible effect of vitamin E administration as an adjunct to scaling and root planing on GCF levels of malondialdehyde and clinical parameters in patients with chronic periodontitis. The adjunctive effect of vitamin E was compared to scaling and root planing alone. Methods: Thirty-two patients with chronic periodontitis participated in this study. They received scaling and sub gingival debridement with either administration of vitamin E (Group I) or placebo (Group II). The primary outcome was to measure the level of Malondialdehyde (MDA) in gingival crevicular fluid (GCF) using the Quantitative Sandwich ELISA technique. In addition, clinical parameters such as PLI,GI, PPD and CAL were recorded at baseline and 3 months after treatment. Results The mean difference between baseline and 3 months scores presented significant difference between the 2 groups with respect to CAL and PD. The test group presented more gain in CAL (0.78mm versus 0.46mm) and more reduction in PD (0.81mm versus 0.41mm). The test group presented higher reduction in GCF level of MDA 3 months posttreatment. However, the difference between groups did not reach statistical significance

Issued also as CD