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Expression of tumor necrosis factor alpha-induced protein 3 gene in patients with pPsoriasis vulgaris / Nahla Yassin Yassin Sahlol ; Supervised Hala Mohamed Safouh , Marwa Salah Mostafa , Lamiaa Abdelfattah Ahmed Madkour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nahla Yassin Yassin Sahlol , 2018Description: 132 P. : facsimiles ; 25cmOther title:
  • التعبير الجينى لبروتين -3 الناتج عن عامل نخر الىرم ألفا فى مرضى الصدفية الشائعة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology Summary: Psoriasis vulgaris is a systemic, immune-mediated disorder characterized by inflammatory skin manifestations. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against harmful side effects of uncontrolled inflammation. A strong association between this molecule and psoriasis vulgaris has been reported. The aim of this study was to compare the expression levels of TNFAIP3 gene in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. In addition, the levels of TNFAIP3 protein in psoriatic skin biopsies from patients were compared to those in normal individuals. Thirty psoriatic patients and thirty healthy participants (control group) were enrolled in the study. The expression levels of TNFAIP3 in blood and skin samples were measured by quantitative reverse transcription PCR and the skin levels of TNFAIP3 protein were measured by western blot technique. Psoriatic patients showed significantly lower levels of TNFAIP3 gene expression in psoriatic skin and blood (P < 0.001) as well as of TNFAIP3 protein in psoriatic skin lesions (P < 0.001) compared to the controls
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.Ph.D.2018.Na.E (Browse shelf(Opens below)) Not for loan 01010110077878000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.Ph.D.2018.Na.E (Browse shelf(Opens below)) 77878.CD Not for loan 01020110077878000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology

Psoriasis vulgaris is a systemic, immune-mediated disorder characterized by inflammatory skin manifestations. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against harmful side effects of uncontrolled inflammation. A strong association between this molecule and psoriasis vulgaris has been reported. The aim of this study was to compare the expression levels of TNFAIP3 gene in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. In addition, the levels of TNFAIP3 protein in psoriatic skin biopsies from patients were compared to those in normal individuals. Thirty psoriatic patients and thirty healthy participants (control group) were enrolled in the study. The expression levels of TNFAIP3 in blood and skin samples were measured by quantitative reverse transcription PCR and the skin levels of TNFAIP3 protein were measured by western blot technique. Psoriatic patients showed significantly lower levels of TNFAIP3 gene expression in psoriatic skin and blood (P < 0.001) as well as of TNFAIP3 protein in psoriatic skin lesions (P < 0.001) compared to the controls

Issued also as CD

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