Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis

Aim of the work: To assess the additive role of contrast enhanced spectral mammography in women with risk of developing breast cancer. Patients and methods: the study included 283 eligible female patients with increased risk of developing breast cancer (i.e. positive family history of breast cancer of first degree relative, personal history of breast cancer and heterogeneously dense mammary parenchyma ), full field digital mammography (FFDM) and contrast enhanced spectral mammography (CESM) were performed, the findings were evaluated independently on both mammography and CESM scanning and final BI-RADS classifications was given in each modality and compared to histopathology results as the golden standard. Results: In total, 283women were enrolled in the study, the mean age of this study population is 48 years. Among the studied cases regardless to a specific risk factor, 15/283(5.3%) cases were diagnosed as normal, 13/283 (4.6%) cases were diagnosed as inflammatory lesions, 72/283(25.4%) cases were diagnosed as benign lesions, 6/283(2.1%) cases were diagnosed as benign precancerous lesions, and 177/283(62.5%) cases were diagnosed as malignant. The overall sensitivity of the CESM was ( 92.7 %) in this study in comparison to mammographic sensitivity (80.90%)while the specificity was (71.43 %) and (59.05 %)respectively

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