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Epigenetic effects of endocrine disruptors on male rats / Maha Mansour Mohammad Rashad ; Supervised Said Zaki Mustafa , Adel M. Elbehairy , Eman Moawad Gouda

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maha Mansour Mohammad Rashad , 2018Description: 114 P. ; 25cmOther title:
  • التاثيرات فوق الجينيه للمواد المسببه لخلل الغدد الصماء فى الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition Summary: The current study was conducted to study the effect of endocrine disruptors (e.g. DBP) on the testicular development and to screen the possible ameliorative role of selenium nanoparticles (Se-NPs) against it in pre- and post-pubertal male rat offspring. Forty-two pregnant female rats treated from gestation day (GD) 12 to postnatal day (PND) 14 day with two doses of Se-NPs (0.2 and 0.5mg/kg/d) against developmental testicular toxicity induced by DBP (500mg/kg/d). At PND 25 (pre puberty) and 60 (post puberty), blood and testes of offspring were collected. Relative testicular weight, total serum testosterone,oxidative stress biomarkers, malodialdehyde (MDA( and reduced glutathione (GSH),relative genes expression for some growth, steroidogenic, antioxidant and apoptotic related genes were evaluated in all groups. The epigenetic changes as methylation analysis of cytochrome C (c-myc) and mineralocorticoid receptors (MR) gene promoters and histopathological examination were also estimated in all groups
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.Ph.D.2018.Ma.E (Browse shelf(Opens below)) Not for loan 01010110078103000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.Ph.D.2018.Ma.E (Browse shelf(Opens below)) 78103.CD Not for loan 01020110078103000

Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition

The current study was conducted to study the effect of endocrine disruptors (e.g. DBP) on the testicular development and to screen the possible ameliorative role of selenium nanoparticles (Se-NPs) against it in pre- and post-pubertal male rat offspring. Forty-two pregnant female rats treated from gestation day (GD) 12 to postnatal day (PND) 14 day with two doses of Se-NPs (0.2 and 0.5mg/kg/d) against developmental testicular toxicity induced by DBP (500mg/kg/d). At PND 25 (pre puberty) and 60 (post puberty), blood and testes of offspring were collected. Relative testicular weight, total serum testosterone,oxidative stress biomarkers, malodialdehyde (MDA( and reduced glutathione (GSH),relative genes expression for some growth, steroidogenic, antioxidant and apoptotic related genes were evaluated in all groups. The epigenetic changes as methylation analysis of cytochrome C (c-myc) and mineralocorticoid receptors (MR) gene promoters and histopathological examination were also estimated in all groups

Issued also as CD

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