Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Operative Dentistry

Objective: The study was conducted to evaluate the effect of 8% arginine based toothpaste in comparison to 8% strontium acetate based toothpaste on dentine hypersensitivity reduction. Materials and methods:This was a randomized, triple-blind, placebo controlled study. Fifty one subjects with a confirmed diagnosis of dentin hypersensitivity were randomized to one of three treatments: Arginine based toothpaste (Colgate Pro-relief), strontium acetate based toothpaste (Sensodyne Rapid Action), or placebo. A standard test stimulus was calibrated short blast of air syringe, applied to sensitive dentin surfaces. Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale at baseline, and after 1 week, 2 weeks and 3 months. Results:All study treatments showed statistically significant reductions from baseline in DH pain at all time points where (p<0.001). 8% arginine based toothpaste (Colgate Pro-relief) was statistically and clinically significant higher when compared with 8% strontium acetate based toothpaste (Sensodyne Rapid Action).These products were shown to be significantly superior to the placebo at all time intervals. Hence, the hypothesis was accepted. Conclusion: 8% arginine based toothpaste and 8% strontium acetate based toothpaste are considered a promising agents that can be used to reduce pain associated with hypersensitivity. It has been shown that there is considerable reduction clinically and statistically significant in dentinal hypersensitivity in the participants under the8% arginine based toothpaste group when compared with the 8% strontium acetate based toothpaste

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