header
Local cover image
Local cover image
Image from OpenLibrary

LRBA/CTLA4 deficiency in children with primary antibody deficiency disorders / Rana Mohamed Adel Ahmed Elrefaie ; Supervised Nancy Mohamed Elguindy , Nermeen Moftah Galal , Safa Sayed Meshaal

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rana Mohamed Adel Ahmed Elrefaie , 2018Description: 133 P. ; 25cmOther title:
  • نقص ل رب أ - س ت ل أ4 فى الاطفال المصابين بأمراض نقص الأجسام المضاده الأولى [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background and aim of work: In the past few years, many genes and different mechanisms were proved to be implicated in various phenotypes of Common Variable Immune Deficiency Disorder (CVID) and yet more to be elucidated. Studying such patients originating from highly consanguineous populations with high incidence of autosomal recessive genetic defects would probably help to unravel new mechanisms and add new explanations. The aim of the present study was to investigate the role of LRBA/CTLA4 in a cohort of CVID patients with detailed description of their clinical and immunological features. Methods: This study included 26 patients with CVID based on ESID criteria for diagnosis of CVID. Nine patients were diagnosed with LRBA deficiency, Two patients had marked defect in CTLA4 expression following T cell stimulation and the rest of the patients with typical CVID phenotype with normal expression of LRBA and CTLA4 proteins. Flow cytometry was used for evaluation of Tregs, assessment of differentiation of T and B lymphocytes and level of LRBA and CTLA4 protein expression
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2018.Ra.L (Browse shelf(Opens below)) Not for loan 01010110078193000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2018.Ra.L (Browse shelf(Opens below)) 78193.CD Not for loan 01020110078193000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background and aim of work: In the past few years, many genes and different mechanisms were proved to be implicated in various phenotypes of Common Variable Immune Deficiency Disorder (CVID) and yet more to be elucidated. Studying such patients originating from highly consanguineous populations with high incidence of autosomal recessive genetic defects would probably help to unravel new mechanisms and add new explanations. The aim of the present study was to investigate the role of LRBA/CTLA4 in a cohort of CVID patients with detailed description of their clinical and immunological features. Methods: This study included 26 patients with CVID based on ESID criteria for diagnosis of CVID. Nine patients were diagnosed with LRBA deficiency, Two patients had marked defect in CTLA4 expression following T cell stimulation and the rest of the patients with typical CVID phenotype with normal expression of LRBA and CTLA4 proteins. Flow cytometry was used for evaluation of Tregs, assessment of differentiation of T and B lymphocytes and level of LRBA and CTLA4 protein expression

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image