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Circulating tumor cells and microsatellite instability in colorectal cancer / Aya Osama Abdelaziz ; Supervised Mostafa Mahmoud Elserafi , Abeer Ahmed Mahmoud Bahnasy , Salem Eid Salem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Aya Osama Abdelaziz , 2018Description: 88 P. : charts , facsimiles ; 25cmOther title:
  • الخلايا السرطانية الجوالة وعدم الاستقرار الكروموسومي في أورام القولون والمستقيم [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical) Summary: Background Microsatellite instability (MSI) is an important piece of information to consider when deciding whether to use adjuvant chemotherapy in patients with stage II colorectal cancer (CRC), it{u2019}s a marker of a more favorable outcome and a predictor of decreased benefit from adjuvant Fluoropyrimidine containing chemotherapy in stage II CRC. Circulating tumor cells (CTC) has shown prognostic and therapeutic implications in breast, colon and prostate cancer. CTC detection by CellSearch System and other sensitive techniques is an easy and highly reproducible method that correlates mostly with tumor stage. Methods This was a retrospective study that included all CRC patients diagnosed and received treatment at NCI Cairo that underwent evaluation of MSI & CTC levels, in the period between 2012 till 2013. MSI assessment was performed by obtaining the paraffin-embedded tissue sections of the tumors from the pathology department, DNA was extracted and amplified using the MSI analysis system which is a fluorescent PCR-based assay. CTC enumeration and identification was done through flow-cytometry and PCR. Collection of blood samples was done before and during treatment. MSI status and CTC level were correlated with the clinical features of the patients, response to treatment and survival
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2018.Ay.C (Browse shelf(Opens below)) Not for loan 01010110078300000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2018.Ay.C (Browse shelf(Opens below)) 78300.CD Not for loan 01020110078300000

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical)

Background Microsatellite instability (MSI) is an important piece of information to consider when deciding whether to use adjuvant chemotherapy in patients with stage II colorectal cancer (CRC), it{u2019}s a marker of a more favorable outcome and a predictor of decreased benefit from adjuvant Fluoropyrimidine containing chemotherapy in stage II CRC. Circulating tumor cells (CTC) has shown prognostic and therapeutic implications in breast, colon and prostate cancer. CTC detection by CellSearch System and other sensitive techniques is an easy and highly reproducible method that correlates mostly with tumor stage. Methods This was a retrospective study that included all CRC patients diagnosed and received treatment at NCI Cairo that underwent evaluation of MSI & CTC levels, in the period between 2012 till 2013. MSI assessment was performed by obtaining the paraffin-embedded tissue sections of the tumors from the pathology department, DNA was extracted and amplified using the MSI analysis system which is a fluorescent PCR-based assay. CTC enumeration and identification was done through flow-cytometry and PCR. Collection of blood samples was done before and during treatment. MSI status and CTC level were correlated with the clinical features of the patients, response to treatment and survival

Issued also as CD

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