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Evaluating galectin-3 (LGALS3) +191 gene variant and serum galectin-3 levels in Egyptian children with familial mediterranean fever / Sara Ibrahim Falah ; Supervised Samia Salah Eldeen Mahmoud , Huda Marzouk Mohamed , Yomna Mohamed Farag

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sara Ibrahim Falah , 2018Description: 131 P. : charts , facsimiles ; 25cmOther title:
  • ومستوي الجلاكتين-3 بالدم في الاطفال المصريين المصابين بحمي البحر المتوسط (LGALS3) تقييم التحور الجيني 191+ لجين الجلاكتين 3 [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Background:The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Galectin-3 is a Ý-galactoside-binding lectin, which regulate cell-cell and extracellular interactions during self /non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis.It plays a significant role in the inflammatory response, the immune response and tissue fibrosis. The aim of the study isto evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of Albumin / Creatinine Ratio (ACR)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2018.Sa.E (Browse shelf(Opens below)) Not for loan 01010110078437000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2018.Sa.E (Browse shelf(Opens below)) 78437.CD Not for loan 01020110078437000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background:The most important and devastating complications of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys leading to end stage renal failure. FMF- related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in prevention and reversing renal amyloidosis. Galectin-3 is a Ý-galactoside-binding lectin, which regulate cell-cell and extracellular interactions during self /non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis.It plays a significant role in the inflammatory response, the immune response and tissue fibrosis. The aim of the study isto evaluate serum galectin-3 level and its gene polymorphism (LGALS3 191 C>A) as a marker of proteinuria and subclinical inflammation in Egyptian children and adolescents with FMF. Methods: Fifty FMF patients in attack free period and 40 healthy children were included as a control group. Serum levels of galectin-3 were measured, Galectin-3 (LGALS3) c.191 C>A (rs4644) gene variant was investigated and morning spot urine was collected for determination of Albumin / Creatinine Ratio (ACR)

Issued also as CD

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