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Correlation between single nucleotide polymorphisms in base excision repair mechanism and HCV associated hepatocellular carcinoma / Manar Aleslam Mohammed Mattar ; Supervised Magdy Ali Amin , Gamal Eldein Esmat Mohamed , Abdelrahman Nabawy Zekri

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Manar Aleslam Mohammed Mattar , 2018Description: 78 P. : charts , facsimiles ; 25cmOther title:
  • العلاقه بين تعدد اشكال النيوكليوتيد المفرد في استئصال قاعدة لاصلاح المسار وسرطان الكبد المرتبط بالاصابه بفيروس سى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology Summary: Base-excision repair genes have a vital role in maintaining the genetic stability of the mammalian cells by repairing DNA damages generated by different factors. However, polymorphisms in these genes could affect the enzyme's activity and may lead to several types of cancer including hepatocellular carcinoma (HCC). Therefore, in the current study, we aimed to determine the possible association between polymorphisms of DNA repair genes, including X-Ray Repair Cross-Complementing group 1 (XRCC1) Arg194Tryp, Arg280His, and Arg399Glu, APE1 Asp148Glu, and NEIL2 Arg257Leu, and the risk of developing hepatitis C virus (HCV)-related HCC. A total of 264 subjects were recruited in this case-control study and were categorized into four groups: 88 control subjects (CR), 53 chronic hepatitis C patients (CHC), 36 liver cirrhotic patients (LC), and 87 HCC patients. The XRCC1 Arg194Tryp, Arg280His, and Arg399Glu polymorphisms were detected using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while real-time PCR was used to genotype APE1 Asp148Glu and NEIL2 Arg257Leu. Our data revealed that, compared with the healthy controls, for those subjects with the XRCC1 Arg194Trp genotype, the risk of developing CHC, LC, and HCC was increased by 6.66- (odds ratio (OR)=6.667; 95% confidence interval (CI)=3.244-13.701; P>0.01), 3.85- (OR=3.852; 95% CI=1.797-8.256; P>0.01), and 2.14-fold (OR=2.14; 95% CI=1.13-4.06; P>0.05), respectively
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2018.Ma.C (Browse shelf(Opens below)) Not for loan 01010110078363000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2018.Ma.C (Browse shelf(Opens below)) 78363.CD Not for loan 01020110078363000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

Base-excision repair genes have a vital role in maintaining the genetic stability of the mammalian cells by repairing DNA damages generated by different factors. However, polymorphisms in these genes could affect the enzyme's activity and may lead to several types of cancer including hepatocellular carcinoma (HCC). Therefore, in the current study, we aimed to determine the possible association between polymorphisms of DNA repair genes, including X-Ray Repair Cross-Complementing group 1 (XRCC1) Arg194Tryp, Arg280His, and Arg399Glu, APE1 Asp148Glu, and NEIL2 Arg257Leu, and the risk of developing hepatitis C virus (HCV)-related HCC. A total of 264 subjects were recruited in this case-control study and were categorized into four groups: 88 control subjects (CR), 53 chronic hepatitis C patients (CHC), 36 liver cirrhotic patients (LC), and 87 HCC patients. The XRCC1 Arg194Tryp, Arg280His, and Arg399Glu polymorphisms were detected using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while real-time PCR was used to genotype APE1 Asp148Glu and NEIL2 Arg257Leu. Our data revealed that, compared with the healthy controls, for those subjects with the XRCC1 Arg194Trp genotype, the risk of developing CHC, LC, and HCC was increased by 6.66- (odds ratio (OR)=6.667; 95% confidence interval (CI)=3.244-13.701; P>0.01), 3.85- (OR=3.852; 95% CI=1.797-8.256; P>0.01), and 2.14-fold (OR=2.14; 95% CI=1.13-4.06; P>0.05), respectively

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