Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Anesthesiology Pain Relief

Design type prospective observational (diagnostic accuracy) study had been done to assess the thickness of diaphragm as a tool for prediction of extubation and proper timing of weaning from mechanical ventilation in the intensive care unit (ICU). It had been measured using B mode ultrasound in ventilated cancer patients. The study had been conducted in the intensive care unit (ICU) - National Cancer Institute - Cairo University. Fifty patients, met spontaneous breathing trial criteria at postoperative period after major elective abdominal cancer surgery with pressure support ventilation, had been enrolled this study.After confirmation of conventional international weaning parameters and weaning protocols in our intensive care unit each patient had been assessed with the ultrasound machine using a linear multifrequency probe (6-13 MHz) and using B-mode to detect the thickness of the diaphragm at zone of apposition.The study was focused on measuring diaphragm thickness and {u2206} tdi% over time during mechanical ventilation as a new predictor of successful weaning and extubation for up to 7 days from time of enrolment or until extubation, which ever happened first

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