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Detection of IDH1 and IDH2 mutations in denovo acute myeloid leukemia patients at National Cancer Institute, Cairo University / Hend Abdelhady Nooh Mahmood ; Supervised Ragia H. Badawy , Yasser H. Elnahhas , Fatma A. Elrefaey

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hend Abdelhady Nooh Mahmood , 2019Description: 187 P. : charts ; 25cmOther title:
  • في حالات سرطان الدم الميلودي الحاد الحديثة التشخيص بالمعهد القومي للاورام - جامعة القاهرة Isocitrate Dehydrogenase (IDH 1,2) كشف الطفرة الجينيه لجيني [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Introduction: AML is characterized by the uncontrolled clonal proliferation of poorly differentiated cells of myeloblasts. Isocitrate dehydrogenases (IDH1&2) are enzymes involved in multiple metabolic and epigenetic cellular processes. Mutations in IDH1 or IDH2 induce production of an oncometabolite, 2-hydroxyglutarate (R-2-HG) which leads to DNA hypermethylation, and abnormal differentiation. IDH mutations diversely affect prognosis of patients with AML based on the presence of other co-occurring genomic abnormalities. Aim of the work : The aim of this study was to assess the frequency of IDH1& IDH2 genes mutations in AML patients and evaluate their role in disease prognosis. Patients and Methods: We analyzed IDH mutations in 70 denovo AML patients (exon 4 for IDH1& exon 4 for IDH2) using High Resolution Melting (HRM) curve analysis
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2019.He.D (Browse shelf(Opens below)) Not for loan 01010110078721000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2019.He.D (Browse shelf(Opens below)) 78721.CD Not for loan 01020110078721000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Introduction: AML is characterized by the uncontrolled clonal proliferation of poorly differentiated cells of myeloblasts. Isocitrate dehydrogenases (IDH1&2) are enzymes involved in multiple metabolic and epigenetic cellular processes. Mutations in IDH1 or IDH2 induce production of an oncometabolite, 2-hydroxyglutarate (R-2-HG) which leads to DNA hypermethylation, and abnormal differentiation. IDH mutations diversely affect prognosis of patients with AML based on the presence of other co-occurring genomic abnormalities. Aim of the work : The aim of this study was to assess the frequency of IDH1& IDH2 genes mutations in AML patients and evaluate their role in disease prognosis. Patients and Methods: We analyzed IDH mutations in 70 denovo AML patients (exon 4 for IDH1& exon 4 for IDH2) using High Resolution Melting (HRM) curve analysis

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