Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology (Pathology)

Background: HNSCC is a common, morbid, and frequently lethal malignancy with SCC representing more than 90% of it.HNSSC is ranked the sixth most common cancer in the world. HPV has been claimed to be another risk factor for its development beside smoking and alcohol. Its prevalence shows great geographic variations. Most studies suggest that patients affected with HR-HPV-cancers have a better prognosis and many clinical trials are trying to prove that such group of patients can receive a different and less aggressive treatment than the HPV negative group.Many detection methods are available for HPV but a frequently recommended strategy is to use a combination of p16 IHC followed by confirmation by DNA ISH.Although such field has received great interest within different countries and continents,African and Egyptian populations are not yet well studied within the literature.Aim of work:To detect the prevalence of HR-HPV in oral and pharyngeal SSC and correlate the viral prevalence with different clinic-pathologic parameters as well as patients{u2019} outcome. Materials and methods:This study included a total of 99 cases from lip(29), tongue(38)& OP(32) diagnosed at the Pathology Department, National Cancer Institute, Cairo-University from Jan 2008 till Dec.2015. p16 IHC was performed on all cases. Only the p16 positive cases were further subjected to HPV DNA ISH

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