Effect of systemic treatment on retinal and choroidal features in vogt-koyanagi-harada (VKH) disease by enhanced depth imaging-optical coherence tomography (EDI-OCT / Dina Nabil Zaki Baddar ; Supervised Onsy Alfy Badei , Nihal Adel Hassan , Dina Hossam Eldin Hassanein

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Vogt{u2013}Koyanagi{u2013}Harada (VKH) disease is a granulomatous inflammatory disorder that affects pigmented structures, namely the inner ear, meninges, skin and eye, in genetically susceptible individuals(1).The choroid is the main site of inflammation in the eye(2). In the acute phase, eyes manifest signs of diffuse choroiditis in the form of focal areas of subretinal fluid and/or bullous serous retinal detachment (1). In the convalescent phase, ocular fundus depigmentation, peripheral chorioretinal depigmented scars and pigmentary changes in the retinal pigment epithelium (RPE) are observed(3) The disease runs a chronic course with recurrence of activity being observed more commonly in the anterior segment(4). Evaluation of VKH disease activity based on clinical examination only has proved to be insufficient. Progressive depigmentation change in RPE of clinically silent VKH disease is observed and is named sunset glow fundus (4). Spectral domain optical coherence tomography (SD-OCT) with enhanced depth imaging function (EDI- OCT) is a new method for the evaluation of the choroid in vivo(5) EDI-OCT provides new data about the choroid, such as its overall thickness measurements as well as successful imaging of presumed choroidal abnormalities(6)

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