Nanoparticles as drug delivery systems for chemo-photothermal laser treatment of cancer cells : Preparation, characterization and evaluation / Dina Samir Aboulfetouh Salem ; Supervised Yehia Abdelhamid Badr , Samia Shouman , Mahmoud Ashour

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Dina Samir Aboulfetouh Salem

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TextLanguage: English Publication details: Cairo : Dina Samir Aboulfetouh Salem , 2019Description: 85 P. : photographs ; 25cmOther title:

جزيئات النانو كنظام توصيل الدواء كعلاج كيميائى حرارى ضوئى ليزرى للخلايا السرطانية : تحضير: توصيف و تقييم [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Sciences and Interactions Summary: Hepatocellular carcinoma (HCC) is one of the most known fatal malignancies. Globally, HCC is the fifth common cancer and it is the second causing death with 745,500 per year due to its poor prognosis. Chronic infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), fatty liver disease, exposure to dietary aflatoxin, alcohol-induced cirrhosis, smoking, obesity, diabetes, and iron overload have been frequently reported to precede the development of HCC. Currently, there is no effective treatment for advanced stages of HCC due to its aggressive nature and poor survival rate. A green method was used for producing gold nanoparticles (Au NPs) using chitosan as a natural cationic, biodegradable and biocompatible polymer. In an attempt to mitigate the side effects of anti-cancer drug, 5-fluorouracil (5-FU), through reducing drug doses in photothermal therapy, the formed positively-charged chitosan-wrapped Au NPs were used as a drug delivery system for negatively charged 5-FU to HepG2. Au NPs as well as 5-FU@Au nanocomposites were characterized by UV-VIS spectroscopy, particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and High-Performance Liquid Chromatography (HPLC)

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.24.12.Ph.D.2019.Di.N (Browse shelf(Opens below))		Not for loan	01010110078937000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.24.12.Ph.D.2019.Di.N (Browse shelf(Opens below))	78937.CD	Not for loan	01020110078937000

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Previous	Cai01.24.12.Ph.D.2017.Em.C Comparative study on the effect of low intensity laser and growth factors on stem cells used in experimentally-induced liver fibrosis in mice /	Cai01.24.12.Ph.D.2019.Am.S Study the role of nanoparticles on photothermal {u2013} chemotherapy combine treatment using laser technology /	Cai01.24.12.Ph.D.2019.Am.S Study the role of nanoparticles on photothermal {u2013} chemotherapy combine treatment using laser technology /	Cai01.24.12.Ph.D.2019.Di.N Nanoparticles as drug delivery systems for chemo-photothermal laser treatment of cancer cells : Preparation, characterization and evaluation /	Cai01.24.12.Ph.D.2019.Di.N Nanoparticles as drug delivery systems for chemo-photothermal laser treatment of cancer cells : Preparation, characterization and evaluation /	Cai01.24.12.Ph.D.2019.Sa.S Synthesis and characterization of III-nitride semiconductor layer using PLD compared with another technique for optoelectronic application /	Cai01.24.12.Ph.D.2019.Sa.S Synthesis and characterization of III-nitride semiconductor layer using PLD compared with another technique for optoelectronic application /	Next

Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Sciences and Interactions

Hepatocellular carcinoma (HCC) is one of the most known fatal malignancies. Globally, HCC is the fifth common cancer and it is the second causing death with 745,500 per year due to its poor prognosis. Chronic infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), fatty liver disease, exposure to dietary aflatoxin, alcohol-induced cirrhosis, smoking, obesity, diabetes, and iron overload have been frequently reported to precede the development of HCC. Currently, there is no effective treatment for advanced stages of HCC due to its aggressive nature and poor survival rate. A green method was used for producing gold nanoparticles (Au NPs) using chitosan as a natural cationic, biodegradable and biocompatible polymer. In an attempt to mitigate the side effects of anti-cancer drug, 5-fluorouracil (5-FU), through reducing drug doses in photothermal therapy, the formed positively-charged chitosan-wrapped Au NPs were used as a drug delivery system for negatively charged 5-FU to HepG2. Au NPs as well as 5-FU@Au nanocomposites were characterized by UV-VIS spectroscopy, particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and High-Performance Liquid Chromatography (HPLC)

Issued also as CD

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